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EC number: 253-575-7 | CAS number: 37640-57-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study performed according to guideline, but no data on substance available and no GLP
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- Deviations:
- no
- GLP compliance:
- no
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic (adaptation not specified)
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): supernatant of homogeneized activated sludge, from the domestic waste water treatment plant of Taunusstein-Bleidenstadt (Germany)
- Duration of test (contact time):
- 28 d
- Initial conc.:
- 10 mg/L
- Based on:
- other: TOC
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Details on study design:
- SAMPLING
- Sampling frequency: day 2, 4, 7, 13, 20, 28 and 30
TEST SYSTEM
- Volume: 3500 mL
CONTROL AND BLANK SYSTEM
- Inoculum blank: yes
- Toxicity control: yes - Reference substance:
- benzoic acid, sodium salt
- Remarks:
- ~ 20 mg/L TOC
- Key result
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 3
- Sampling time:
- 28 d
- Remarks on result:
- other: average of the 2 tests
- Details on results:
- Test 1:6% within 28 days
Test 2: 0% within 28 days
The test substance did not show toxicity to the inoculum. - Results with reference substance:
- 20 mg/L = 90% biodegradation, > 60% biodegradation where observed after 5 days
- Validity criteria fulfilled:
- not specified
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- The test substance is not readily biodegradable.
Reference
Sampling day | Concentration: 126 mg/3.5 L (ThCO2: 128.7 mg CO2/3.5 L) | |
mg CO2 (cumulative) | % TCO2 (= % degradation) | |
2 | 0.76 | 1 |
5 | 1.27 | 1 |
7 | 1.93 | 1 |
13 | 3.64 | 3 |
20 | 5.31 | 4 |
28 | 7.52 | 6 |
30 | 10.99 | 9 |
Sampling day | Concentration: 127 mg/3.5 L (ThCO2: 129.7 mg CO2/3.5 L) | |
mg CO2 (cumulative) | % TCO2 (= % degradation) | |
2 | 0.25 | < 1 |
5 | 0.60 | y 1 |
7 | 0.68 | 1 |
13 | 0.80 | 1 |
20 | -0.42 | / |
28 | -1.17 | / |
30 | 0.03 | < 1 |
Total CO2 evolution of the blank test: 65.3 mg CO2 / 3500 mL within 28 days
Description of key information
Not readily biodegradable (by OECD criteria).
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
- Type of water:
- freshwater
Additional information
The substance has been tested according OECD 301B with a concentration of the test item exceeding the solubility limit by the factor 16. Practically no indication of biodegradation was observed.
Furthermore, several studies conducted with melamine and cyanuric acid themselves are available.
For the component 108 -78 -1(Melamine):
Test results of a MITI test for ready biodegradability, 3 Zahn-Wellens assays for inherent biodegradability and 2 studies on Biochemical Oxygen Demand are reported. The individual results of the studies are consistent: Melamine is not readily biodegradable and also not inherently biodegradable.
With activated sludge taken from an industrial waste water treatment plant as the inoculum, a degradation of DOC of up to 16 % was observed within 20 d (Pagga 1991). A rapid and complete primary degradation of the molecule within 8 h was detected with an activated sludge taken from an industrial waste water treatment plant from a producer of melamine (Fimberger 1997). Addition of glucose, in the absence of NH4+, enables the microorganisms to use melamine as the only nitrogen source (Fimberger 1997). Degradation occurs by hydrolytic deamination to ammeline, ammelide and cyanuric acid, and lastly to CO2 and NH4+ (Fimberger 1997).
For the component 108 -80 -5 (Cyanuric acid):
The component is neither readily not inherently biodegradable.
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