Fatty acids, C16-18, esters with ethylene glycol

Basic toxicokinetics

Administrative data

Endpoint:

basic toxicokinetics in vitro / ex vivo

Type of information:

migrated information: read-across based on grouping of substances (category approach)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

publication

Title:

Unnamed

Year:

1958

Materials and methods

Objective of study:

other: enzymatic hydrolysis of propylene glycol distearate

Principles of method if other than guideline:

In vitro enzymatic hydrolysis of propylene glycol distearate by steapsin at 30°C.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Propylene glycol distearate

IUPAC Name:

Propylene glycol distearate

Constituent 2

Reference substance name:

Propylene distearate

EC Number:

228-229-3

EC Name:

Propylene distearate

Cas Number:

6182-11-2

Molecular formula:

C39H76O4

IUPAC Name:

propane-1,2-diyl dioctadecanoate

Radiolabelling:

yes

Test animals

Species:

other: in vitro; in glycerol-bile salts solution

Strain:

other: not applicable

Sex:

not specified

Administration / exposure

Details on study design:

IN VITRO HYDROLYSIS RATE OF PROPYLENE GLYCOL DISTEARATE
The method described by Balls and Matlock (Balls, A.K. and Matlock, M.B., 1938. J. Biol. Chem. 123, 679) was applied in the study with modifications. The percent of hydrolysis was calculated by titration of free fatty acids after 0, 5, 30 and 45 min and 1, 3 and 19.5 h.

Results and discussion

Metabolite characterisation studies

Details on metabolites:

After the in vitro hydrolysis of PGDS by steapsin, the in vitro study indicated that PGDS was capable of undergoing hydrolysis to yield free fatty acids.