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Inhalation exposure of humans at 695 mg/m3 for 4 hours showed increased CO-Hb levels and decreased tracking performance, as well as a decline in response time in the visual-peripheral component of dual-tasking. Based on human data dichloromethane might be irritating to the respiratory tract at high concentrations. There is no direct indication that dichloromethane is a sensitizer of any practical significance in humans. Limited epidemiological studies suggest long-term occupational exposures in the range of 174-1677 mg/m3 may not produce overt signs of neuro- or hepatotoxicity. No consistent relationships between dichloromethane and cancer at any particular site have been reported in studies of workers exposed to dichloromethane. There is no strong epidemiological evidence to suggest that dichloromethane is harmful to fertility or during pregnancy.