Registration Dossier
Registration Dossier
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EC number: 203-630-6 | CAS number: 108-93-0
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
Data source
Reference
- Reference Type:
- publication
- Title:
- Dermal Absorption Potential of Industrial Chemicals: Criteria for Skin Notation
- Author:
- Fiserova-Bergerova V, Pierce TJ, Droz PO
- Year:
- 1 990
- Bibliographic source:
- American Journal of Industrial Medicine 17: 617-635
Materials and methods
- Principles of method if other than guideline:
- The dermal penetration rate (flux) was predicted from physical properties
Test material
- Reference substance name:
- Cyclohexanol
- EC Number:
- 203-630-6
- EC Name:
- Cyclohexanol
- Cas Number:
- 108-93-0
- Molecular formula:
- C6H12O
- IUPAC Name:
- cyclohexanol
- Test material form:
- solid
- Details on test material:
- Not applicable for in silico study.
Constituent 1
Results and discussion
Any other information on results incl. tables
A calculated dermal flux of 1.26 mg/cm2 per hour was reported in the publication for cyclohexanol. A dermal uptake of 2520 mg/hour can then be estimated (assumptions: 2000 cm2 of skin surface area exposed to cyclohexanol in solution).
Applicant's summary and conclusion
- Conclusions:
- The model predicts skin penetration of cyclohexanol based on the physical chemical properties of the substance.
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