Registration Dossier
Registration Dossier
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EC number: 233-042-5 | CAS number: 10025-78-2
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 946
- Report date:
- 1946
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 951
- Report date:
- 1951
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- other
- GLP compliance:
- no
Test material
- Reference substance name:
- Trichlorosilane
- EC Number:
- 233-042-5
- EC Name:
- Trichlorosilane
- Cas Number:
- 10025-78-2
- Molecular formula:
- Cl3HSi
- IUPAC Name:
- trichlorosilane
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Amount / concentration applied:
- 1% and 5% dilutions in "Deobase" (deodorized kerosene) were evaluated by instillation into rabbits' eyes.
3-minute exposures to 250 and 500 ppm dose levels were evaluated.
Results and discussion
In vivo
Results
- Irritation parameter:
- other:
- Remarks on result:
- other:
- Remarks:
- 5% dilution in "Deobase" (deodorized kerosene) ruined rabbit eyes. 1% dilution produced minor damage. The compound is relegated to grade 9 in a 10-grade rating system for eye burns. A 3-minute exposure of rabbit eyes to 500 ppm of vapor produced immediate opacity of the cornea. A concentration of 250 ppm gave no damage that was immediately detectable, but which become apparent 3 hours later. This was considered as a delayed burn.
Any other information on results incl. tables
5% dilution in "Deobase" (deodorized kerosene) ruined rabbit eyes
1% dilution produced minor damage.
The compound is relegated to grade 9 in a 10-grade rating system for eye burns
A 3-minute exposure of rabbit eyes to 500 ppm of vapor produced immediate opacity of the cornea. A concentration of 250 ppm gave no damage that was immediately detectable, but which become apparent 3 hours later. This was considered as a delayed burn.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In an in vivo eye irritation study, not conducted according to OECD Test Guideline or GLP, 5% dilution in "Deobase" (deodorized kerosene) ruined rabbit eyes whereas 1% dilution produced minor damage. The compound was relegated to grade 9 in a 10-grade rating system for eye burns. A 3-minute exposure of rabbit eyes to 500 ppm of vapor produced immediate opacity of the cornea. A concentration of 250 ppm gave no damage that was immediately detectable, but which become apparent 3 hours later and considered as a delayed burn.
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