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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Review, peer-reviewed data
Cross-reference
Reason / purpose:
reference to same study

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
Selected non-hetrocyclic polycyclic aromatic hydrocarbons.
Author:
WHO
Year:
1998
Bibliographic source:
Environmental Health Criteria 202, Geneva, Switzerland, WHO (World Health Organisation) 1998
Reference Type:
review article or handbook
Title:
Unnamed
Year:
2003

Materials and methods

Principles of method if other than guideline:
Review evaluating peer-reviewed data

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Main ADME resultsopen allclose all
Type:
absorption
Results:
PAH are absorbed through the pulmonary tract, the gastrointestinal tract, and the skin. Absorption rate from lung depends on type of PAH. Gastrointestinal absorption is rapid in rodents with metabolites returning to the intestine via biliary excretion.
Type:
distribution
Results:
PAH are widely distributed throughout the organism after administration by any route and are found in almost all internal organs, but particularly those rich in lipids.
Type:
metabolism
Results:
Metabolism is via intermediary epoxides which are further transformed by rearrangement or hydration to phenols or dihydrodiols. Secondary oxidation yield tetrols. Hydroxylated metabolites can be conjugated with sulphuric or glucuronic acid or gluthatione.
Type:
excretion
Results:
PAH metabolites and their conjugates are excreted via the urine and faeces. Conjugates may be hydrolysed by gut flora after biliary excretion and be reabsorbed. With increasing size, excretion into faeces increases. PAH seem not to persist in the body.

Applicant's summary and conclusion