Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 205-599-4 | CAS number: 143-33-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
The systemic toxicity of cyanides is sufficiently high that systemic intoxication and death are likely to occur before the development of inflammatory irritation effects on the skin or in the eye. Protection of workers for acute toxicity effects will protect them from irritation effects, as well.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
The conduct of irritation studies according to established protocols is not technically feasible, due the high acute systemic toxicity of cyanide compounds at the required doses. The systemic toxicity of cyanides is sufficiently high that systemic intoxication and death are likely to occur before the development of inflammatory irritation effects on the skin or in the eye. Commercial solutions of cyanide salts are maintained at a basic pH (11), so that any irritation which may result from exposure cannot be ascribed specifically to cyanide itself. Respiratory irritancy can not be excluded especially with the solution, but due to the high systemic toxicity potential appropriate measures have to be applied to avoid inhalation of the substances. Additional risk management measures include gloves, boots and protective clothing to protect against both acute toxicity and skin, eye and respiratory irritation.
Justification for classification or non-classification
Cyanide salts are not classified as irritants. Acute systemic toxicity from dermal or respirtory absorption is a more critical health effect . However, workers will be protected from potential irritation as risk management measures including personal protective equipment (gloves, boots, respirators, etc) are required to prevent systemic toxicity from dermal or inhalation exposure.
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