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EC number: 250-954-9
CAS number: 32210-23-4
a limit acute dermal toxicity study performed before but similarly to
the OECD guideline No. 402, groups of young adult albino New Zealand
rabbits (3/sex) were occlusively exposed to undiluted test material for
24 hours at dose of 5 mL/kg bw (ca. 4680mg/kg bw; density = 0.936). The
animals were observed for mortality, clinical signs including dermal
reactions and body weight for 14 days and then necropsied for
mortality occurred during the study and no clinical signs were observed.
There was no adverse effect on bodyweight gain. Slight to moderate
erythema was observed during the first 24 hours after application. All
rabbits exhibited a slight scaliness over the treated area, which was
first observed on Day 8 and persisted to the end of the study.
LD50Combined > 5 mL/kg bw (> 4680 mg/kg bw)
the test conditions, the test material is not classified according to
the Regulation EC No. 1272/2008 (CLP) and to the GHS.
study is considered as acceptable and satisfies the requirement for
acute dermal toxicity endpoint.
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