4-tert-butylcyclohexyl acetate

Endpoint summary

Description of key information

Acute data with varying reliabilities (Klimisch rating), based on international or national guidelines, are available for three trophic levels: Algae, Invertebrates, Fish and Microorganisms. These data are summarised in the table below:

Level of exposure / trophic levels	Organism	EC50/LC50	NOEC	Flag / reliability	Performing laboratory	Reference in IUCLID
Acute / Aquatic algae	Scenedesmus subspicatus	72h: 22 mg/L (growth rate)	72h: 6.8 mg/L (biomass)	K/2	Hüls	Toxicity to aquatic algae and cyanobacteria, Scholz, 1997, RS, K
Acute / Aquatic invertebrates	Daphnia magna	48h: 5.3 mg/L	48h: Not determined	K/2	Unilever Research	Short-term toxicity to aquatic invertebrates, Marshall, 1994, RS, K
Acute / Aquatic invertebrates	Daphnia magna	24h: 7 mg/L	24h: Not determined	S/2	Hüls	Short-term toxicity to aquatic invertebrates, Scholz, 1995, SS, S
Acute / Fish	Cyprinus carpio	96h: 8.6 mg/L	96h: Not determined	K/1	Hüls	Short-term toxicity to fish, Scholz, 1997, RS, K
Acute / Fish	Leuciscus idus melanotus	48h: 15 mg/L	48h: Not determined	S/4	Hüls	Short-term toxicity to fish, Scholz, 1996, SS, S
Acute / Micro-organisms	activated sludge	3h: 302 mg/L	3h: 122 mg/L	K/1	Hüls	Toxicity to microorganisms, Diefenbach, 1997, RS, K
Acute / Microorganisms	Pseudomonas putida	6h: Not determined	6h: 1.15 mL/L	S/2	Hüls	Toxicity to microorganisms, Diefenbach, 1996, SS, S

Among all data available, the aquatic invertebrate,Daphnia magna,is the most sensitive species with a 48h-EC50 at 5.3 mg/L.For algae and fish, the L(E)C50 values were determined at 22 mg/L (based on growth rate) and 8.6 mg/L, respectively.For microorganisms, the 3h-EC50 and 3h-EC10 values were determined at 302 mg/L and 122 mg/L respectively.

In accordance with column 2 of REACH annex IX, further testing on the long-term effects on aquatic organisms does not need to be conducted as the chemical safety assessment does not indicate a need for further investigation.