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EC number: 256-032-2
CAS number: 42978-66-5
In-vivo, a skin irritation test was performed
with three New Zealand White rabbits, according to OECD guideline 404
and in compliance with GLP (reliability 1). At least 24 hours before
substance administration the dorsolateral part of the trunk of the
animals was clipped. The untreated skin sites of the animals served as
control. A 4-hour semiocclusive
exposure to ca. 0.5 ml of the undiluted test substance produced the
following effects: slight eryrthema (grade 1) was observed in two
animals immediately and 1 hour after removal of the patch and persisted
in one animal up to 24 hours. Moderate erythema (grade 2), noted in one
animal immediately and 1 hour after removal of the patch, decreased to
slight erythema after 24 hours. No other cutaneous reactions were
observed during the study. The cutaneous reactions were reversible in
one animal within 24 hours and in two animals within 48 hours after
removal of the patch.
Based on this study findings the test item
was considered to be non iriitating to the skin of rabbits.
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