Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 256-032-2 | CAS number: 42978-66-5
Endpoint summary
Administrative data
Description of key information
Additional information
Short-term toxicity to fish: With high probability acutely toxic to fish.
Key study: BASF AG (1988, report no. 10F0158/885179). DIN 38412-15, Leuciscus idus:
- 96-h LC50 = 4.6 – 10 mg/L (nom.)
Long-term toxicity data to fish: no data available.
no data available. Information requirement waived based on the results of the chemical safety assessment (no PBT/vPvB; RCR < 1).
Short term toxicity to aquatic invertebrates:With high probability acutely harmful to aquatic invertebrates.
Key study: BASF AG (1988, report no. 1/0671/2/88-0671/88): EU method C.2, Daphnia magna:
48-h EC50 = 89 mg/L (nom.)
Long-term toxicity to aquatic invertebrates:no data available. Information requirement waived based on the results of the chemical safety assessment (no PBT/vPvB; RCR < 1).
Toxicity to aquatic algae and cyanobacteria: Acutely toxic to aquatic algae.
Key study: BASF AG (1988, report no. 88/0671): DIN 38412 p. 9, Desmodesmus subspicatus:
72-h ErC50 = 65.9 mg/L (nom.)
72-h ErC10 = 6.6 mg/L (nom.)
Toxicity to aquatic microorganisms: The inhibition of the degradation activity of activated sludge is not anticipated when introduced in appropriately low concentrations.
Weight-of-evidence - 30 -min EC 50 > 1000 mg/L:
TPGDA (CAS 42978-66-5): short-term respiration inhibition study (Robra), Pseudomona putida (BASF AG, 1988, rep.no.: 01/88/0671):
30 -min EC10 > 10000 mg/L (nom.), EC50 > 10000 mg/L (nom.)
Structurally similar substance CAS 57472-68-1: short-term respiration inhibition study according to OECD 209, domestic activated sludge (GLP; BASF AG, 2002, rep. no.: 02/0368/08/1)
30-min EC20 > 1000 mg/L (nom.)
Conclusion:Based on the available experimental data, TPGDA (CAS 42978-66--5) is considered to be acutely toxic to aquatic organisms.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
