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Endpoint:
additional toxicological information
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
Structure-toxicity relationship of acrylates and methacrylates.
Author:
Tanii H, Hashimoto K
Year:
1982
Bibliographic source:
Toxicol. Lett. 11: 125-129

Materials and methods

Type of study / information:
other: Structure-toxicity relationship
Principles of method if other than guideline:
The acute oral toxicity (LD50), the partition coefficient (P), and the second order rate constant (K) with reduced glutathione were measured experimentally.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Butyl methacrylate (Tokyo Kasei Inc.), purity not specified

Results and discussion

Any other information on results incl. tables

For butyl methacrylate the oral LD50 in mice was 142.70 mmol/kg (20.292 mg/kg), 

log  P was 2.88 and log K -0.655; the toxicities of acrylates and  methacrylates

were found to be dependent upon log P or log K; the  correlation coefficient 

between log (1/LD50) and log P was -0.9909 for  acrylates and -0.795 for 

methacrylates (both statistically significant);  the correlation coefficient 

between log P and log K was -0.935 for  acrylates and -0.744 for methacrylates.

----+-------+--------+--------+--------+-------+-------
    |  Oral LD50 (mmol/kg) a) | Log P  | Log K |   K
    | Range |  from  -  to    |   b)   |   c)  |   e)
----+-------+--------+--------+--------+-------+-------
MA     9.60     6.895   13.36    0.80    1.602   39.994
EA    17.97    12.27    26.35    1.33    1.428   26.792
nBA   58.98    46.62    74.44    2.36    1.000   25.177
iBA   47.63    47.63    d)       2.22    1.431   26.977
HEA    5.177    4.325    6.20   -0.21    1.919   82.985
HPA    8.112    6.623    9.932   0.35    1.758   57.280
MMA   51.97    39.03    69.22    1.38   -0.675    0.211
EMA   68.64    51.62    91.25    1.94   -0.403    0.395
iPMA  67.84    49.75    92.39    2.25   -0.876    0.133
nBMA 142.70   116.50   174.80    2.88   -0.655    0.221
iBMA  83.14    65.80   105.00    2.66   -0.769    0.170
tBMA  60.12    45.15    80.10    2.54   -0.632    0.233
HEMA  45.24    33.20    61.65    0.47   -0.273    0.533
HPMA  55.24    34.29    88.92    0.97   -0.273    0.533
----+-------+--------+--------+--------+-------+-------

a) Acute oral LD50 was determined according to Weil [12] and expressed as  the mean (95 % confidence interval)
b) Values are the mean of four determinations.
c) Values are the mean of four determinations.
d) s.dev. = 0.0000
e) Rem: K [liter mol-1 min-1] has been re-calculated from logK; test  conditions: 37 °C, 0.1 M phosphate buffer, pH 7.3, 150 µM KCN, ester and  GSH: 10 mM

MA = Methyl acrylate; EA = Ethyl acrylate; nBA = n-Butyl acrylate; iBA =  Isobutyl acrylate; HEA = 2-Hydroxylethyl acrylate; HPA = 2-Hydroxylpropyl  acrylate; MMA = Methyl methacrylate; EMA = Ethyl methacrylate; iPMA =  Isopropyl methacrylate; nBMA = n-Butyl methacrylate; iBMA = Isobutyl  methacrylate; tBMA = tert-Butyl methacrylate; HEMA = 2-Hydroxyethyl  methacrylate; HPMA = 2-Hydroxypropyl methacrylate

Applicant's summary and conclusion

Conclusions:
Using a valid scientific method, for butyl methacrylate the oral LD50 in mice was 142.70 mmol/kg (20.292 mg/kg), 
log  P was 2.88 and log K -0.655; the toxicities of acrylates and  methacrylates were found to be dependent upon log P or log K.
Executive summary:

Using a valid scientific method, for butyl methacrylate the oral LD50 in mice was 142.70 mmol/kg (20.292 mg/kg),  log  P was 2.88 and log K -0.655; the toxicities of acrylates and  methacrylates were found to be dependent upon log P or log K.