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Toxicological information

Repeated dose toxicity: oral

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Administrative data

Endpoint:
sub-chronic toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Original reference in a foreign language, and not yet available

Data source

Reference
Reference Type:
publication
Title:
Effects of Halogens on an Organism
Author:
Tswapo V V, VN Kupyrov, RK Gakol et al.
Year:
1975
Bibliographic source:
Gig Sanit 6:92-93 English summary from Chem Abstr 83:14261r

Materials and methods

Principles of method if other than guideline:
Rats were given bromine in drinking water. Behavioral and reflex observations, blood and blood chemistry analysis, examination of internal organs were conducted.
GLP compliance:
not specified
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Although this study cites bromine as the test article, when addded to drinking water, elemental bromine is not likely to be present. The test article, thus, would actually be hypobromous acid and other brominated oxidants formed.

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: drinking water
Duration of treatment / exposure:
Six month exposure
Frequency of treatment:
Daily
Doses / concentrationsopen allclose all
Remarks:
Doses / Concentrations:
0.01 mg/kg
Basis:
nominal in water
Remarks:
Doses / Concentrations:
Unspecified lower doses
Basis:
nominal in water

Results and discussion

Results of examinations

Details on results:
Reported effects included altered behavior, decreased erythrocyte and leukocyte counts, decreased hemoglobin levels, lower cholinesterase and alkaline phosphatase activity, decreased phagocytic action of neutrophils, and increased ascorbate content of the adrenal glands. Unspecified lower doses of bromine did not significantly alter conditioned reflexes, blood indicies or internal organs.

Effect levels

Dose descriptor:
LOAEL
Effect level:
0.01 mg/kg bw/day (nominal)

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion

Conclusions:
In a 6 month study with rats given 0.01 mg/kg bromine in drinking water, reported effects included altered behavior, decreased erythrocyte and leukocyte counts, decreased hemoglobin levels, lower cholinesterase and alkaline phosphatase activity, decreased phagocytic action of neutrophils, and increased ascorbate content of the adrenal glands. Unspecified lower doses of bronime did not significantly alter conditioned reflexes, blood indicies or internal organs.
Executive summary:

In a 6 month study with rats given 0.01 mg/kg bromine in drinking water, reported effects included altered behavior, decreased erythrocyte and leukocyte counts, decreased hemoglobin levels, lower cholinesterase and alkaline phosphatase activity, decreased phagocytic action of neutrophils, and increased ascorbate content of the adrenal glands. Unspecified lower doses of bronime did not significantly alter conditioned reflexes, blood indicies or internal organs.