Registration Dossier

Administrative data

Description of key information

Bromine is classified/labelled with the symbol “C” and the risk phrase  “R35”.
Dunn et al. (1967) showed that bromine is a corrosive material when applied to rabbit skin for less than one minute. A five second exposure with removal by acetone wiping produced necrosis. Severity of corrosion was increased with occlusion, even in a 10% solution. When bromine liquid was applied neat with five second washout, it was corrosive to rabbit eyes.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (corrosive)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

Bromine is classified/labelled with the symbol “C” and the risk phrase “R35”. Data in humans have identified that minor eye irritation occurs at levels of 0.3 mg/m3.


Effects on skin irritation/corrosion: highly corrosive

Effects on eye irritation: highly corrosive

Effects on respiratory irritation: highly irritating

Justification for classification or non-classification

Bromine is classified/labelled with the symbol “C” and the risk phrase “R35”.