Registration Dossier
Registration Dossier
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EC number: 231-778-1 | CAS number: 7726-95-6
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Data waiving:
- other justification
- Justification for data waiving:
- other:
Data source
Reference
- Reference Type:
- publication
- Title:
- Bromine Poison Information Monograph 080
- Author:
- International Programme on Chemical Safety
- Bibliographic source:
- INCHEM (PIM 080)
Materials and methods
Results and discussion
Applicant's summary and conclusion
- Executive summary:
The reactivity of bromine in biological systems makes it difficult to study the pharmacokinetics and to separate the effects of bromine from those of the bromine compounds and metabolites that are formed on contact with moisture in mucous membranes and with tissues of the respiratory and gastrointestinal system. Due to its reactivity, bromine does not persist as an element in living tissue, but quickly forms bromide. In this form, it may be deposited in the tissues, displacing other halogens (Sticht and Kaferstein, 1988). Bromide pharmacokinetics are well known from use of bromides as therapeutics. Biological half-life for bromide through ingestion is 12 to 30 days.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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