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Toxicological information

Direct observations: clinical cases, poisoning incidents and other

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Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
other: clinical observation
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Bromine Gassing
Author:
Suntych F
Year:
1970
Bibliographic source:
Prac Lek 5:86, 1953

Materials and methods

Study type:
poisoning incident
Endpoint addressed:
acute toxicity: inhalation

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Bromine
- Physical state: vapor
- Other: accidental exposure in workplace to unknown concentration

Method

Type of population:
occupational
Subjects:
- Number of subjects exposed: 8
- Sex:
- Age:
- Race:
- Demographic information:
- Known diseases:
- Other:
Ethical approval:
not applicable
Route of exposure:
inhalation
Reason of exposure:
unintentional, occupational
Exposure assessment:
not specified

Results and discussion

Clinical signs:
Bronchopneumonia in three victims, blepharospasm in one and chronic laryngitis in the remainder. Death occurred in one case as a result of sudden circulatory failure associated with bronchopneumonia.
Outcome of incidence:
One death.

Applicant's summary and conclusion

Conclusions:
Accidental acute occupational exposure to an unknown concentration of bromine vapor resulted in clinical signs of blepharospasm (1 of 8), and respiratory distress (resulting from bronchopneumonia in 3/8) and chronic laryngitis in the remainder. One patient died of circulatory failure in association with the bronchopneumonia.
Executive summary:

Accidental acute occupational exposure to an unknown concentration of bromine vapor resulted in clinical signs of blepharospasm (1 of 8), and respiratory distress (resulting from bronchopneumonia in 3/8) and chronic laryngitis in the remainder. One patient died of circulatory failure in association with the bronchopneumonia.