Registration Dossier

Administrative data

Description of key information

Skin: The skin irritation potential has been examined in studies performed by the Annex V method (Phycher 2003d, 2003e, 2003f). Nickel nitrate was a skin irritant in the tests.
Eye: The eye irritation potential has been examined in studies performed by the Annex V method (Phycher 2003g, 2003h, 2003i). Nickel nitrate was an eye irritant in the tests and irritation was still observed at the end of the 21-day observation period.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

ENDPOINT SUMMARY INFORMATION FROM THE 2008/2009 NICKEL DINITRATE RISK ASSESSMENT:

In the Annex V tests in rabbits, nickel nitrate was a skin irritant. Based on this data, classification as Xi; R38 is warranted.

In the Annex V tests in rabbits, nickel nitrate was an eye irritant and the effects were not reversible within the 21-day observation period. Based on this data, classification as Xi; R41 is warranted.


Effects on skin irritation/corrosion: irritating

Effects on eye irritation: irritating

Justification for classification or non-classification

Ni nitrate is classified as Xi;38 and Skin Irrit. 2: H315 in the 1st ATP to the CLP Regulation. It is also classified as Xi;R41 and Eye Dam.1; H318. Background information regarding these classification has been provided in the discussion section.