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EC number: 203-180-0 | CAS number: 104-15-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Study period:
- July 5-19, 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline not specified, but with detailed documentation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Guideline:
- other: no information about guideline provided
- Deviations:
- not specified
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- ammonium xylene sulfonate
- IUPAC Name:
- ammonium xylene sulfonate
- Details on test material:
- - Name of test material (as cited in study report): ammonium xylene sulfonate (AXS)
- Molecular formula (if other than submission substance): no data
- Molecular weight (if other than submission substance): no data
- Substance type:
- Physical state: liquid
- Analytical purity: no data
- Impurities (identity and concentrations): no data
- Composition of test material, percentage of components: no data
- Lot/batch No.: 8694K
- Expiration date of the lot/batch: no data
- Stability under test conditions: stable
- Storage condition of test material: no data
- Other: specific gravity = 1.121 at 25 degrees Centigrade
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Boswell
- Age at study initiation: young adult
- Weight at study initiation: 2.50-2.98 kilograms
- Fasting period before study: no data
- Housing:individually in metal cages elevated above droppings
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 14 days minimum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): no data
- Humidity (%): no data
- Air changes (per hr):no data
- Photoperiod (hrs dark / hrs light): no data
IN-LIFE DATES: From: July 5, 1979 To:July 19, 1979
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: trunk
- % coverage: no data
- Type of wrap if used: plastic binder with adhesive tape
- Other: Prior to exposure, the trunks of the animals were clipped free of hair and the skin examined. Only those animals without skin defects or irritation were used for the study. The skin was further prepared by making epidermal abrasions every two or three centimeters longitudinally over the area of exposure. The abrasions were sufficiently deep to penetrate the stratm corneum but not deep enough to disturb the derma.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): wiped with absorbent paper towel
- Time after start of exposure: 24 hours
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): no data other than enough to cover the treatment site
- Concentration (if solution): undiluted
- Constant volume or concentration used: yes
VEHICLE
- Amount(s) applied (volume or weight with unit): no vehicle - Duration of exposure:
- 24 hours
- Doses:
- 0.5 and 2.0 g /kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observations on day of dosage and daily (5 days per week) for 14 days; weighing on day of dosage and 7 days post treatment
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs including erythema, edema, thickening, dryness, desquamation, papules
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- No mortalities occurred in the study
- Clinical signs:
- other: At 24 hours all animals showed a moderate erythema and a minimal to moderate edema at the treatment site. This initial dermal reaction was followed by the usual sequelae of redness, thickening, dryness and desquamation, which persisted in varying degrees
- Gross pathology:
- Two animals (a male at 0.5 g/kg bw and a male at 2.0 g/kg bw) had wrinkling and fissuring of the cortex of both kidneys. All other organs and tissues were not remarkable.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The dermal LD50 on male and female rabbits is greater than 2000 mg/kg body weight.
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