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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Due to the low vapour pressure, the technically highest attainable concentration is approximately 1.8 mg/m3 (0.29 ppm) when the test substance is evaporated at 20°C (concentration not determined), which is below any limit concentration.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1966
Report date:
1966

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Principles of method if other than guideline:
Inhalation risk test
GLP compliance:
no
Test type:
other: Inhalation risk test
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
2,2',2''-nitrilotriethanol
EC Number:
203-049-8
EC Name:
2,2',2''-nitrilotriethanol
Cas Number:
102-71-6
Molecular formula:
C6H15NO3
IUPAC Name:
2-[bis(2-hydroxyethyl)amino]ethan-1-ol

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
other: unchanged (no vehicle)
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
8 h
Concentrations:
Saturated TEA atmosphere (concentration not given).
No. of animals per sex per dose:
6 males, 6 females
Control animals:
no
Details on study design:
- Duration of observation period following administration: 7 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC0
Exp. duration:
8 h
Remarks on result:
other: saturated TEA atmosphere (approximately 1.8 mg/m3)
Mortality:
0/12
Clinical signs:
other: no clinical signs reported
Body weight:
mean body weight gain: 17.25 g
Gross pathology:
1 chronic bronchitis, all other animals without findings

Applicant's summary and conclusion