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EC number: 295-433-7 | CAS number: 92045-52-8 A complex combination of hydrocarbons obtained from a catalytic hydrodesulfurization process. It consists predominantly of hydrocarbons having carbon numbers predominantly in the range of C4 through C11 and boiling in the range of approximately 30°C to 250°C (86°F to 482°F).
Unleaded gasoline vapor was administered by inhalation to Fischer 344 rats and B6C3F mice for 6 hours/day, 5 days/week for up to 113 weeks at analytical vapor concentrations of 322, 1402, and 9869 mg/m3to assess inhalation toxicity. No consistent, compound-related changes were seen in mortality, hematology or clinical chemistry parameters in either species. Significant depression of body weight gain was seen in both sexes of rats and male mice exposed to the highest level of gasoline vapor. On gross necropsy, a compound-related increase in liver nodules and masses was seen in female mice exposed to the highest dose level. In addition, male rats exposed to gasoline vapor at all concentrations exhibited primary kidney neoplasms, correlated histopathologically with an increase in the incidence and severity of regenerative epithelial changes and dilated tubules containing proteinaceous material. The kidney effects observed in male rats are indicative of alpha-2u-globulin nephropathy. Alpha-2u-globulin nephropathy, also known as hyaline droplet nephropathy, results from the formuation of complexes with a naturally occurring protein (alpha-2u-globulin) in the kidneys of male rats. These complexes can accumulate in the proximal renal tubule and may produce species-specific histopathological changes. Based on the decreased body weight gain at the highest dose, the no observed adverse effect concentration (NOAEC) was 1402 mg/m3.
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