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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Published study to non-standard guidelines (Stratmann et al, 1979); results are also summarised in later papers by Stratmann (1979) and Stratmann & Eifinger (1981).
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
[Teratological aspects of CaF2 medication]
Author:
Stratmann KR, Eifinger FF & Köhler F
Year:
1979
Bibliographic source:
Deutsche Zahnarztliche Zeitschrift 1979, Feb; 34(2):124-6
Reference Type:
publication
Title:
[TOXICOLOGICAL THRESHOLD VALUES OF VARIOUS FLUORIDE COMPOUNDS]
Author:
STRATMANN KR & EIFINGER FF
Year:
1981
Bibliographic source:
KARIESPROPHYLAXE 3:15-17,1981
Reference Type:
publication
Title:
[Comparison of embryotoxic effects of inorganic fluorides]
Author:
Stratmann KR
Year:
1979
Bibliographic source:
Deutsche Zahnarztliche Zeitschrift 1979, Jun; 34(6):484-6

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
The acute intraperitoneal toxicity of the substance in the mouse was investigated as a range-finding study for a study of developmental toxicity.
GLP compliance:
no
Remarks:
: published study, pre-dates GLP
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Calcium fluoride
EC Number:
232-188-7
EC Name:
Calcium fluoride
Cas Number:
7789-75-5
Molecular formula:
CaF2
IUPAC Name:
calcium difluoride
Test material form:
other: solid
Details on test material:
No additional details are reported

Test animals

Species:
mouse
Strain:
ICR
Sex:
female
Details on test animals or test system and environmental conditions:
No further information

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
not specified
Details on exposure:
No further information
Doses:
0 (control), 25, 50, 100, 200, 400, 800, 1600, 3200 or 6400 mg/kg bw
No. of animals per sex per dose:
5-15 pregnant females per dose level
Control animals:
yes
Details on study design:
No further information
Statistics:
No further information

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LD50
Effect level:
2 778 mg/kg bw
Remarks on result:
other: gravid
Mortality:
Deaths occurred at 3200 mg/kg bw (8/9) and at 6400 mg/kg bw (5/7).
Clinical signs:
No further information
Body weight:
No further information
Gross pathology:
No further information
Other findings:
No further information

Any other information on results incl. tables

The acute intraperitoneal LD50 of calcium fluoride in gravid female mice was calculated to be 2778 mg/kg bw

Applicant's summary and conclusion

Conclusions:
The test substance was shown to be of low toxicity under the conditions of this study.
Executive summary:

A single dose of calcium fluoride was administered by intraperitoneal injection to gravid female mice on day 9 of gestation at dose levels of between 25 and 6400 mg/kg bw. The acute intraperitoneal LD50 of calcium fluoride in gravid female mice was calculated to be 2778 mg/kg bw under the conditions of this study. The intraperitoneal LD50 of calcium fluoride in gravid female mice is additionally reported in a later paper by the same authors to be 2638.27 mg/kg bw; this value may represent a re-interpretation of the same data.