Registration Dossier
Registration Dossier
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EC number: 212-782-2 | CAS number: 868-77-9
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption
- Type of information:
- other: QSPR
- Remarks:
- Based on an established human skin model by Potts and Guy (Potts RO and Guy RH (1992). Predicting Skin Permeability. Pharm. Res. 9(5): 663-669)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Generally accepted calculation method
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
- Principles of method if other than guideline:
- The physicochemical parameters of MW, Log P and saturated aqueous solubility have been used in the evaluation of 56 methacrylate compounds. An output of predicted steady-state flux was calculated using the principles defined in the Potts and Guy prediction model. (Potts RO and Guy RH (1992). Predicting Skin Permeability. Pharm. Res. 9(5): 663- 669)
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-hydroxyethyl methacrylate
- EC Number:
- 212-782-2
- EC Name:
- 2-hydroxyethyl methacrylate
- Cas Number:
- 868-77-9
- Molecular formula:
- C6H10O3
- IUPAC Name:
- 2-hydroxyethyl methacrylate
- Details on test material:
- TS-Freetext:
other dental series, Chemotechnique
Constituent 1
Test animals
- Species:
- other: human skin model
- Details on test animals or test system and environmental conditions:
- not applicable; in silico modelling
Administration / exposure
- Type of coverage:
- other: not applicable; in silico modelling
- No. of animals per group:
- not applicable; in silico modelling
Results and discussion
- Absorption in different matrices:
- predicted flux 151.3 μg/cm²/h; the relative dermal absorption is high
Any other information on results incl. tables
Based on a molecular weight of 130.1 g/mol and a g Kow of 0.42, the predicted flux of HPMA is 151.3 μg/cm²/h; the relative dermal absorption is high.
Applicant's summary and conclusion
- Conclusions:
- The dermal absorption of HEMA is predicted to be high; the predicted flux is 151.3 μg/cm²/h.
- Executive summary:
- The dermal absorption (steady-state flux) of HEMA has been estimated
by calculation using the principles defined in the Potts and Guy
prediction model.
Based on a molecular weight of 130.1 g/mol and a logKow of 0.42, the predicted flux of HEMA is 151.3μg/cm²/h; the relative dermal absorption is high.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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