Registration Dossier
Registration Dossier
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EC number: 272-489-0 | CAS number: 68855-54-9
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The acute toxicity of kieselguhr soda ash flux calcined to rainbow trout was investigated in a GLP study performed in accordance with OECD Guideline 203. The 96 h EC50 was >100% v/v saturated solution and the NOEC was 100% v/v saturated solution.
Key value for chemical safety assessment
Additional information
The key study (Priestly 2010) was performed to OECD Guideline 203 and in accordance with GLP. The study assessed the acute toxicity torainbow trout in a limit test. Pre-study solubility work indicated that a solution of the test item could not be attained using conventional methods, for example, ultrasonication or high shear mixing. Given the insoluble nature of the test item and also its high purity value, it was considered that the most suitable method of preparation was as a saturated solution. Following a preliminary range-finding test fish were exposed, in two groups of seven, to an aqueous solution of the test item, at a single concentration of 100 % v/v saturated solution for a period of 96 hours. The number of mortalities and any sub-lethal effects of exposure in each test and control vessel were determined 3 and 6 hours after the start of exposure and then daily throughout the test until termination after 96 hours. The 96-Hour LC50based on nominal test concentrations was greater than 100% v/v saturated solution and correspondingly the No Observed Effect Concentration was 100 % v/v saturated solution.
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