Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 297-907-9 | CAS number: 93763-87-2 Substance formed by processing of chiefly oxidic material with lead and zinc content in a rotating furnace. Consists primarily of Al2O3, CaO, Fe, FeO and SiO2 with other nonferrous compounds as well as carbon.
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study, key study used in EU risk assessment report for Zinc metal
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Zinc
- EC Number:
- 231-175-3
- EC Name:
- Zinc
- Cas Number:
- 7440-66-6
- Molecular formula:
- Zn
- IUPAC Name:
- zinc
- Details on test material:
- - Name of test material (as cited in study report): Zincstaub, superfein 620
- Other: Zinc powder particle diameter was 5 micrometer
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- no further details provided
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- maize oil
- Details on oral exposure:
- In this study very fine zinc powder, labelled as “Zincstaub, superfein 620”, was given as a suspension in maize oil
- Doses:
- one dose of 2000 mg zinc/kg bw
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
- Details on study design:
- no further information
- Statistics:
- no information
Results and discussion
- Preliminary study:
- no information
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- no mortality observed
- Clinical signs:
- piloerection in all females, diarrhoea in one female
- Body weight:
- no adverse effects reported
- Gross pathology:
- no adverse effects reported
- Other findings:
- none
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- LD50 >2000 mgZn/kgbw
- Executive summary:
A limit study with Wistar rats was carried out according to OECD guideline no. 401 to assess the oral LD50. Apart from piloerection in all females and diarrhoea in one female, no mortality or clinical signs were observed after dosing of 2000 mg zinc/kg bw during the 14 day observation period. In this study very fine zinc powder, labelled as “Zincstaub, superfein 620”, was given as a suspension in maize oil. The particle size was not given in this study, but according to the accompanying letter from the industry the particle diameter was 5 μm. An LD50-value of > 2000 mg Zn/kg bw was reported
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