Registration Dossier
Registration Dossier
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EC number: 270-671-4 | CAS number: 68476-30-2 A distillate oil having a minimum viscosity of 32.6 SUS at 37.7°C (100°F) to a maximum of 37.9 SUS at 37.7°C (100°F).
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Multiple studies were available to assess the skin sensitising potential of VGOs/HGOs/Distillate fuels. In the first key study (Klimisch score = 2, API 1980a), dermal sensitisation potential of diesel fuel was evaluated, while the second key study (Klimisch score = 2, ), evaluated dermal sensitisation potential of #2 home heating oil. Under the conditions of this test, diesel fuel and # 2 home heating oil were considered to be non-sensitising as there was no significant difference in response to the test material between the test and control groups.
In supporting studies (API 1980b, ARCO 1990d, 1988g, 1986g, 1986h, 1986i; Klimisch scores = 2, ARCO 1993h, 1987m; API 1980), VGOs/HGOs/Distillate fuels were not found to be sensitisers to guinea pigs.
Based on these results,VGOs/HGOs/Distillate fuels are not skin sensitisers when tested using a closed patch technique in guinea pigs.
Migrated from Short description of key information:
VGOs/HGOs/Distillate fuels are not skin sensitisers when tested using a closed patch technique in guinea pigs (OECD 406).
Justification for selection of skin sensitisation endpoint:
One of eleven guinea pig sensitisation studies, all of which showed no evidence of skin sensitisation.
Justification for classification or non-classification
VGO/Hydrocracked/Distillate fuels are not classified as sensitising to the skin according to the EU CLP Regulation (EC) 1272/2008.
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