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Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (sensitising)
Additional information:

Substance specific information for the UVCB substance “Slimes and Sludges, precious metal refining” is not available for the endpoint "Sensitisation". In order to meet the requirements for Annex VII till Annex X of Regulation (EC) 1907/2006, read across information from any constituents being relevant needs to be included. Due to the high number of constituents and variability in C&L of these constituents it was decided to use the classification information from the individual constituents and to calculate the resulting classification by using the generic concentration limits of ingredients of the mixture classified as a specific target organ toxicant that trigger classification of the mixture and respective rules of Regulation (EC) 1272/2006 section 3.4.3.2 “Classification of mixtures when data are available for all components or only for some components of the mixture” with the MeClas tool. This approach has been presented and discussed with ECHA in several meetings

 

In total, four different grades of "Slimes and Sludges, precious metal refining" (composition profile 1 - composition profile 4) were identified by the consortium that could be grouped according to their calculated C&L resulting from the specific composition profile. Thus, for "Slimes and Sludges, precious metal refining" two C&L entries for skin and respiratory sensitisation (i.e., no C&L and sensitisation) were generated. Each group is described in a separate endpoint study record and endpoint summary.

Migrated from Short description of key information:
No information on animal testing of “Slimes and Sludges, precious metal refining" is available. Since, “Slimes and Sludges, precious metal refining" (composition profile 3 - composition profile 4) contains a constituent ≥ 0.1 % (i.e., soluble Pd substances, nickel chloride) that may cause skin sensitisation (Skin Sens. 1); the substance must be classified as being a skin sensitiser “Skin Sens. 1 (H317)”. It is noted that no sub-categorisation was performed

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (sensitising)
Additional information:

Substance specific information for the UVCB substance “Slimes and Sludges, precious metal refining” is not available for the endpoint "Sensitisation". In order to meet the requirements for Annex VII till Annex X of Regulation (EC) 1907/2006, read across information from any constituents being relevant needs to be included. Due to the high number of constituents and variability in C&L of these constituents it was decided to use the classification information from the individual constituents and to calculate the resulting classification by using the generic concentration limits of ingredients of the mixture classified as a specific target organ toxicant that trigger classification of the mixture and respective rules of Regulation (EC) 1272/2006 section 3.4.3.2 “Classification of mixtures when data are available for all components or only for some components of the mixture” with the MeClas tool. This approach has been presented and discussed with ECHA in several meetings

 

In total, four different grades of "Slimes and Sludges, precious metal refining" (composition profile 1 - composition profile 4) were identified by the consortium that could be grouped according to their calculated C&L resulting from the specific composition profile. Thus, for Slimes and Sludges, precious metal refining two C&L entries for skin and respiratory sensitisation (i.e., no C&L and sensitisation) were generated. Each group is described in a separate endpoint study record and endpoint summary.

Migrated from Short description of key information:
No information on animal testing of “Slimes and Sludges, precious metal refining" is available. “Slimes and Sludges, precious metal refining" (composition profile 3 - composition profile 4) contains at least one constituent ≥ 0.1 % (w/w) (i.e., nickel chlorde) that may cause respiratory sensitisation “Resp.Sens. 1” (H334). Hence, the UVCB meets classification criteria for respiratory sensitisation “Resp.Sens. 1” (without sub-categorising) in accordance with Regulation (EC) 1272/2008.

Justification for classification or non-classification

Skin sensitisation

“Slimes and Sludges, precious metal refining” (composition profile 3 - composition profile 4) possesses a skin sensitisation potential and requires classification for skin sensitisation in accordance with Regulation (EC) 1272/2008 Skins. Sens. 1 (H317: May cause an allergic skin reaction.).

 

Respiratory sensitisation

“Slimes and Sludges, precious metal refining” (composition profile 3 - composition profile 4) contains at least one constituent ≥ 0.1 % (w/w) (i.e., nickel chloride) that may cause respiratory sensitisation Category 1 (H334). Hence, the substance meets classification criteria for respiratory sensitisation “Resp.Sens. 1” (without sub-categorising) and requires labelling with H334 (may cause allergy or asthma symptoms or breathing difficulties if inhaled) in accordance with Regulation (EC) 1272/2008.