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Toxicological information

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Description of key information

No information on animal testing of "Slimes and Sludges, precious metal refining" on acute toxicity is available. The C&L of "Slimes and Sludges, precious metal refining" - composition profile 1 was determined by using the “acute toxicity range estimate (ATE)” and respective rules of Regulation (EC) 1272/2006 section 3.1.3.6 “Classification of mixtures based on ingredients of the mixture”. Applying these rules, "Slimes and Sludges, precious metal refining" - composition profile 1 does not requires classification as acutely toxic via ingestion, inhalation and after skin contact.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
discriminating dose
Value:
2 000 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
discriminating conc.
Value:
5 000 mg/m³

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
discriminating dose
Value:
2 000 mg/kg bw

Additional information

Substance specific information for the UVCB substance "Slimes and Sludges, precious metal refining" as such is not available for the endpoint "Acute Toxicity". In order to meet the requirements for Annex VII - Annex X of Regulation (EC) 1907/2006, read across information from any constituent being relevant needs to be included. Due to the high number of constituents and variability in C&L of these constituents it was decided to use the classification information from the individual constituents and to calculate the resulting classification by using the “acute toxicity range estimate (ATE)” and respective rules of Regulation (EC) 1272/2006 section 3.1.3.6 “Classification of mixtures based on ingredients of the mixture” with the aid of the MeClas tool. This approach has been presented and discussed with ECHA in several meetings.

In total, four different grades of "Slimes and Sludges, precious metal refining" (composition profile 1 - composition profile 4) were identified by the consortium that could be grouped according to their calculated C&L resulting from the specific composition profile. Thus, for "Slimes and Sludges, precious metal refining" four C&L entries for acute toxicity were generated. Each group is described in a separate endpoint study record and endpoint summary.

Justification for classification or non-classification

The available information indicates that "Slimes and Sludges, precious metal refining" - composition profile 1 does not require classification as acutely toxic or harmful via ingestion and inhalation in accordance with Regulation (EC) 1272/2008. Furthermore, "Slimes and Sludges, precious metal refining" - composition profile 1 does not meet classification criteria as acutely toxic or harmful via skin exposure in accordance with Regulation (EC) 1272/2008.

Specific target organ toxicant (STOT) - single exposure: oral, inhalation and dermal

The classification criteria according to Regulation (EC) 1272/2008 as specific target organ toxicant (STOT) – single exposure are not met since no adverse health effects, including reversible and irreversible, were observed immediately or delayed after exposure.