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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Proprietary study reported in summary form only
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1979

Materials and methods

Test guideline
Qualifier:
no guideline followed
Deviations:
not applicable
Principles of method if other than guideline:
The study method is broadly comparable to OECD 405
GLP compliance:
no
Remarks:
(the study pre-dates GLP)

Test material

Constituent 1
Chemical structure
Reference substance name:
Chromium hydroxide sulphate
EC Number:
235-595-8
EC Name:
Chromium hydroxide sulphate
Cas Number:
12336-95-7
Molecular formula:
CrHO5S
IUPAC Name:
chromium hydroxide sulphate
Details on test material:
The test material is referred to by the tradename 'Chromsal B'

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not required
Duration of treatment / exposure:
Single exposure; no details on washing
Observation period (in vivo):
7 days
Number of animals or in vitro replicates:
Two

Results and discussion

In vivo

Results
Irritation parameter:
other: scores for eye irritation not reported.
Time point:
other: Not applicable
Other effects:
Not detailed

Any other information on results incl. tables

The scores for eye irritation are not reported, however it is stated that the test material was not found to be a primary eye irritant in this study.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The test material was not irritating to the rabbit eye under the conditions of this study
Executive summary:

50 mg of the test material was instilled into one eye of two New Zealand White rabbits; ocualr reactions were observed for 7 days. Scores for eye irritation are not reported, however the test material was not irritating to the rabbit eye under the conditions of this study.

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