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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Proprietary study reported in summary only
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1979

Materials and methods

Test guideline
Qualifier:
no guideline followed
Deviations:
not applicable
Principles of method if other than guideline:
The test method used 24-hour exposure of the interior surface of the rabbit ear
GLP compliance:
no
Remarks:
study pre-dates GLP

Test material

Constituent 1
Chemical structure
Reference substance name:
Chromium hydroxide sulphate
EC Number:
235-595-8
EC Name:
Chromium hydroxide sulphate
Cas Number:
12336-95-7
Molecular formula:
CrHO5S
IUPAC Name:
chromium hydroxide sulphate
Details on test material:
The test material is referred to as 'Chromsal B'

Test animals

Species:
rabbit
Strain:
New Zealand White

Test system

Type of coverage:
semiocclusive
Preparation of test site:
not specified
Vehicle:
unchanged (no vehicle)
Controls:
not required
Duration of treatment / exposure:
24 hours
Observation period:
7 days
Number of animals:
two

Results and discussion

In vivo

Other effects:
Not reported

Any other information on results incl. tables

Results are not reported in detail, however the report states that the test material is not irritating to skin.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Although the irritation scores are not reported, it is concluded that the test material is not a skin irritant.
Executive summary:

500 mg of the test material was applied under semi-occlusive conditions to the interior surface of the ears of two New Zealand White rabbits. Residual test material was removed after 24 hours by washing with soap and water; animals were obsereved for 7 days. Scores for irritation are not reported, however it is stated in the report that the test material was not a skin irritant under the conditions of the study. The study protocol is not standard, however it can be concluded that the substance is not a skin irritant.

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