Registration Dossier

Diss Factsheets

Administrative data

Description of key information

Proprietary studies of skin irritation and eye irritation are available for the material 'Chromsal B' (chromium hydroxide sulphate /  sodium sulphate).  The studies are not reported in detail but clearly show that the substance is not a skin or eye irritant.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Additional information

A proprietary study of skin irritation was performed to a non-standard protocol. However the exposure method used in this study (24 -hour application to the interior surface of the rabbit ear) is noted to be more stringent than specified under the current OECD guideline 404. The finding in this study that the test material is non-irritating to skin is therefore acceptable.

A proprietary study of eye irritation was performed to a protocol broadly comparable to the current OECD guideline 405. The test material was found to be non-irritating under the conditions of this study.

Although the studies are not reported in great detail and are not performed in strict compliance with current guidelines, they indicate that the substance is not irritating to the skin or eyes. This conclusion is supported by the absence of findings of irritation in humans following occupational exposure. Further testing for skin and eye irritation is therefore not justified on scientific or animal welfare grounds.

Justification for classification or non-classification

The results of the studies performed with 'Chromsal B' are relevant and applicable to the substance. Based on the results of these studies and the absence of findings in occupationally exposed workers, no classification for skin or eye irritation is proposed.

Categories Display