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Administrative data

Description of key information

A proprietary acute oral toxicity study is available for the material 'Chromsal B', which shows low toxicity.  No information on acute dermal toxicity is available, however toxicity by this route can be predcited to be very low based on the low acute oral toxicity and very low dermal penetration.  A waiver is therefore propoosed for acute dermal toxicity testing. 

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
LD50
Value:
3 530 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Dose descriptor:
LC50
Value:
4 580 mg/m³

Additional information

A proprietary acute oral toxicity study is available for the material 'Chromsal B' (chromium hydroxide sulphate / sodium sulphate), which shows low toxicity. This study was reported briefly, but in sufficient detail to enable confident evaluation of the method and the reliability of the results. The calculated LD50 from this study of 3530 mg/kg bw shows that the substance is of low toxicity by this route.

No information on acute dermal toxicity is available, however toxicity by this route can be predicted to be very low based on the low acute oral toxicity and very low dermal penetration of Cr (III) compounds. A waiver is therefore proposed for acute dermal toxicity; testing is not justified on scientific or animal welfare grounds.

A proprietary acute inhalation study was performed. Male and female Han Wistar rats underwent a single 4 -hour nose only inhalation exposure to chromium hydroxide sulphate at a mean atmospheric exposure level of 4.58 mg/L. The test compound was poorly tolerated, causing persistent clinical signs. Seven out of ten animals died during the course of the study. The LC50 is therefore considered to be below 4.58 mg/L. This shows that the substance can be classified as ‘Harmful by inhalation.’

Justification for classification or non-classification

Chromium hydroxide sulphate is not classified for acute oral toxicity based on experimental data showing very low toxicity and is not classified for acute dermal toxicity based on low oral toxicity and very low dermal penetration. For acute inhalation toxicity the substance can be classified as 'harmful by inhalation.'

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