Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
dermal absorption in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence

Data source

Materials and methods

Test material

Constituent 1
Chemical structure
Reference substance name:
Chromium hydroxide sulphate
EC Number:
235-595-8
EC Name:
Chromium hydroxide sulphate
Cas Number:
12336-95-7
Molecular formula:
CrHO5S
IUPAC Name:
chromium hydroxide sulphate

Results and discussion

Percutaneous absorption
Remarks on result:
other:

Applicant's summary and conclusion

Executive summary:

A number of toxicokinetics studies are available showing that dermal absorption of chromium (III) is very poor.  The FIOH document (2006) discusses several dermal absorption studies of chromium (III) compounds and concludes that the low skin permeability of chromium (III) compounds is due to skin barrier rejection of the positive chromium ions.  A review by the UK Health and Safety Executive (1989) found that approximately 2% of administered chromium (III), administered in the form of highly water-soluble chromium chloride, was dermally absorbed by guinea pigs after 5 hours.  No further testing is therefore required;  the HSE has estimated dermal exposure for an exposure duration appropriate to occupational and consumer exposure.