Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 231-906-6 | CAS number: 7778-50-9
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Study period:
- 14/12/1982-25/2/1983
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline-comparable proprietray study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- no
- Remarks:
- Pre-dates GLP
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Sodium chromate
- EC Number:
- 231-889-5
- EC Name:
- Sodium chromate
- Cas Number:
- 7775-11-3
- IUPAC Name:
- disodium dioxido(dioxo)chromium
- Reference substance name:
- Sodium dichromate
- EC Number:
- 234-190-3
- EC Name:
- Sodium dichromate
- Cas Number:
- 10588-01-9
- Reference substance name:
- Potassium dichromate
- EC Number:
- 231-906-6
- EC Name:
- Potassium dichromate
- Cas Number:
- 7778-50-9
- Molecular formula:
- K2Cr2O7
- IUPAC Name:
- sodium dichromate
- Details on test material:
- Yellow powder (sodium chromate)
Orange/red powder (sodium dichromate)
Orange/red powder (potassium dichromate)
Constituent 1
Constituent 2
Constituent 3
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Cheshire Farms, Ltd
- Age at study initiation: 10-12 weeks
- Weight at study initiation: 1.67-2.71 kg
- Fasting period before study: Not stated
- Housing: Individual
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: 14 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 10-24
- Humidity (%): 40-82
- Air changes (per hr): Not reported
- Photoperiod (hrs dark / hrs light): Not reported
IN-LIFE DATES: From: 14/12/82 To: 25/2/83
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- physiological saline
- Details on dermal exposure:
- TEST SITE
- Area of exposure: Approximately 26.4 cm2
- % coverage: 10
- Type of wrap if used: occlusive tape
REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes
- Time after start of exposure: 24 hours
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2 g/kg
- Concentration (if solution): moistened with saline (0.15 ml/g)
- Constant volume or concentration used: yes
VEHICLE
- Amount(s) applied (volume or weight with unit): 2 ml/kg
- Concentration (if solution): -
- Lot/batch no. (if required): -
- Purity: - - Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- Five
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Daily observation; bodyweights recorded on Days 1, 4, 7, 11 and 14
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, organ weights (brain, lungs, liver, spleen, kidneys, gonads), necropsy - Statistics:
- Homogenity of variance (F Max); Student's t-test; Wilcoxon Rank Sum test.
Results and discussion
- Preliminary study:
- Not reported
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Remarks on result:
- other: Sodium dichromate
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- < 2 000 mg/kg bw
- Remarks on result:
- other: Sodium dichromate
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Remarks on result:
- other: Sodium dichromate
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Remarks on result:
- other: Sodium chromate
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Remarks on result:
- other: Sodium chromate
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Remarks on result:
- other: Sodium chromate
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Remarks on result:
- other: Potassium dichromate
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Remarks on result:
- other: Potassium dichromate
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Remarks on result:
- other: Potassium dichromate
- Mortality:
- Sodium chromate: no males died; one female died on Day 4
Sodium dichromate: One male died on Day 1; three females died on Days 1-6
Potassium dichromate: No males died; two females died between Days 3-6 - Clinical signs:
- other: Sodium chromate: Green staining, hypokinesia, sneezing, swellilng of the application site Sodium dichromate: Yellow staining, hypokineisa, swollen or encrusted application site Potassium dichromate: Green/blue/yellow.red staining, hunched posture, ataxia,
- Gross pathology:
- Gross necropsy did not reveal any effects clearly related to treatment in any group.
- Other findings:
- Mean absolute and relative liver weights were seen in females administered sodium dichromate. No effects were seen on other organ weights and similar effects were not seen in any of the other treated groups.
Any other information on results incl. tables
The significantly lower liver weights seen in females treated with sodium dichromate are not considered to be of toxicological significance as they are associated with low concurrent control values.
Liver weight |
Sodium chromate |
Controls |
Sodium dichromate |
Controls |
Potassium dichromate |
Controls |
||||||
M |
F |
M |
F |
M |
F |
M |
F |
M |
F |
M |
F |
|
Absolute (g) |
103 |
111 |
110 |
110 |
111 |
116** |
116 |
91 |
106 |
103 |
116 |
98 |
Relative (%) |
4.4 |
4.9 |
4.3 |
4.3 |
4.3 |
5.4** |
4.1 |
3.5 |
4.3 |
4.8 |
4.3 |
4.4 |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Acute dermal LD50 values for all of the Cr (VI) compounds investigated in this study were found to be >2000 mg/kg bw (combined sexes). Females appeared to be slightly more sensitive than males to each of the compounds and 3/5 females administered sodium dichromate died.
- Executive summary:
Sodium chromate, sodium dichromate and potassium dichromate (moistened with saline) were administered for 24 hours under occluive conditions to the shorn dorsal skin of groups of New Zealand White Rabbits (5/sex). Animals were observed for 14 days.
Deaths occurred in the groups treated with sodium chromate (1F), sodium dichromate (1M, 3F) and potassium dichromate (2F). Signs of systemic toxcity and local dermal effects were observed in each treatment group. Bodywieghts were unaffected by treatment. Gross necropsy did not reveal any clearly treatment-related effects. Significantly higher absolute and relative liver weights seen in sodium dichromate-treated animals are associated with low concurrnet controls and are considered to be of minimal toxicological significance.
The acute dermal LD50 values for each of the compounds investigated was therefore found to be >2000 mg/kg bw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
