Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

A skin sensitization study performed according to Magnusson and Kligman Guinea-Pig Maximization test (OECD TG 406) found no indication of skin sensitization in guinea pigs for Hydrocarbons, C9 aromatics. Hydrocarbons, C9 aromatics are not skin sensitizers or photosensitizers in humans. Hydrocarbons, C9 Aromatics were evaluated for its ability to induce skin sensitization in a 26 person Human Repeated Insult Patch Test (HRIPT). In addition, the ability to induce a phototoxic or photocontact response was determined by comparing irradiated and non-irradiated skin sites. Application to the skin without or in conjunction with UV irradiation did not elicit a sensitizing or photosensitizing response in any of the study participants.


Migrated from Short description of key information:
Hydrocarbons, C9 Aromatics were negative using a Magnusson and Kligman Guinea-Pig Maximization test (OECD TG 406). Hydrocarbons, C9 Aromatics were negative in a Human Repeated Insult Patch Test (HRIPT).

Respiratory sensitisation

Endpoint conclusion
Additional information:

There are no reports of respiratory sensitization from C9 Aromatics in laboratory animals or humans.  A skin sensitization study utilizing C9 Aromatics found no indication of skin sensitization in guinea pigs.  Additional studies in humans also found no indication of skin sensitization.  With these observations, it is presumed that C9 Aromatics will not be a respiratory sensitizing agent.


Migrated from Short description of key information:
no data

Justification for classification or non-classification

These findings do not warrant the classification of C9 Aromatic hydrocarbon solvents as a skin or respiratory sensitizer under the new Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP) or under the Directive 67/518/EEC for dangerous substances and Directive 1999/45/EC for preparations.