Registration Dossier
Registration Dossier
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EC number: 249-862-1 | CAS number: 29806-73-3
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
No toxic effects up to the limit of water solubility for Brachydanio rerio (OECD 203)
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 10 000 mg/L
Marine water fish
Marine water fish
- Effect concentration:
- 1 800 mg/L
Additional information
There are no studies on fish toxicity available for 2-ethylhexyl palmitate (CAS No. 29806-73-3). The assessment of fish toxicity was therefore based on a study conducted with the structurally most similar category member, for which data is available, isopropyl palmitate (CAS 142-91-6), as part of a read across approach, which is in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5. Grouping of substance and read across approach. Further justification is given within the endpoint summary 6.1 and within the category justification section 13. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance was entered into IUCLID. Nevertheless, as can be seen in the data matrix of the category justification in Section 13, all reliable data in the category support the hazard assessment for this endpoint, by showing a consistent pattern of results.
The key study with isopropyl palmitate (CAS No. 142-91-6), was performed according to the guideline ISO 7346-1 (similar to OECD 203), in a semi-static system, using Brachydanio rerio as test organism (Richterich, 2001). The fish were exposed to nominal test concentrations of 1000, 3000 and 10,000 mg/L during 96 hours. No mortality was observed at any of the test concentrations, and the LC50 was reported to be > 10,000 mg/L.
Thus, based on theabove mentioned result, and due to the structural and profile similarities of the two substances, as are explained with in the overall endpoint summary 6.1 it can be concluded that no toxicological effects on fish are expected up tothe limit ofwater solubility for 2-ethylhexyl palmitate (CAS No. 29806-73-3)
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