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EC number: 231-592-0 | CAS number: 7646-85-7
Table 1: Outcome of mating by zinc treated male rats
Number of females mated
Number of females conceived
Normal live litter
Number / mated female
*Difference was significant at 5% level
Table 2: Zinc content of the reproductive tissues of zinc treated male rats
28.1± 1.63 (15)
35.3 ± 2.13 (18)*
58.3 ± 3.46 (10)
61.4 ± 6.63 (10)
24.4 ± 3.25 (10
33.8 ± 5.96 (10)
48.8 ± 6.90 (10)
51.7 ± 6.36 (10)
559 ± 14.8 (10)
658 ± 24.7 (10)*
Results expressed as Mean ± SEM in µg/g, except for sperm in µg/g dw, for the number of
rats shown in parentheses.
* P < 0.02
Table 3: Motility and viability of the sperm of zinc treated rats
Motility (Emmen's unit)
25.9 ± 0.57
23.7 ± 0.47*
23.7 ± 0.58
17.7 ± 1.15**
17.2 ± 1.10
12.2 ± 1.42*
% viable at 4 hours
55.7 ± 4.80
49.0 ± 4.60
Values expressed as Mean ± SEM for the number of rats shown in parentheses.
* P < 0.01
**P < 0.001
A study was conducted to determine the effects of dietary zinc supplementation on male fertility in Charles-Foster rats.
4,000 ppm zinc as zinc sulphate was fed to 18 test males in diet for 30 -32 d. 15 control males were fed normal diet for the same duration. All animals mated with individual normal females once between Day 30 and 32. After mating, males were sacrificed for sperm characterization and zinc concentration analysis in different reproductive organs. Mated females were allowed to have full term gestation.
Mating by treated males caused significant lowering of incidence of conception and number of live births per mated female. However, no stillbirth or malformed litter was observed. Motility of the sperm was significantly reduced in the treated rats but viability was unaffected. Zinc content was significantly increased only in the testis and sperm of the treated rats.
The results indicate that dietary zinc supplementation at 4,000 ppm reduced male fertility in rats under the conditions of the study.
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