Registration Dossier

Administrative data

Description of key information

Zinc chloride is corrosive based on animal skin irritation studies. Due the corrosive nature of zinc chloride to skin, eye irritation studies do not need to be conducted and hence no animal eye irritation data is available on zinc chloride. 

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

The soluble zinc compounds (i. e., zinc chloride, zinc sulphate and diammonium tertachlorozincate), displayed in vivo varying degrees of skin and eye irritation ranging from moderate to severely irritating.

Based on the available data of the soluble zinc compounds, soluble zinc chloride is classified as corrosive (C; R34) according to EC criteria due to severe skin irritancy seen in animals at concentrations of 1% solution and irreversible damage to eyes caused by zinc chloride after accidental exposure in humans. Zinc chloride has also shown signs of respiratory tract irritation in single exposure studies (see acute inhalation toxicity).

On the other hand zinc sulphate was not irritating to skin but is a severe eye irritant and has been classified as a severe eye irritant (Xi R41) according to EC criteria.

In vitro data shows that zinc bis(dihydrogen phosphate) was not irritating to skin. While no in vivo data exists on zinc bis(dihydrogen phosphate),in vitro data suggests zinc bis(dihydrogen phosphate) is moderately irritating to eyes. Diammonium tetrachlorozincate appears to be a moderate eye irritant however no classification has been assigned. While no specific irritation data were identified for triammonium pentachlorozincate, it is (due to its similar solubility characteristics) likely to display a toxicity profile similar to that of the soluble diammonium tetrachlorozincate.



Effects on skin irritation/corrosion: highly irritating

Effects on respiratory irritation: irritating

Justification for classification or non-classification

Zinc chloride is classified as corrosive (C;R34) or Skin Corr 1B; H314 according to EC criteria due to severe skin irritancy seen in animals at concentrations of 1% solution and irreversible damage to eyes caused by zinc chloride after accidental exposure in humans. Zinc chloride has also shown signs of respiratory tract irritation in single exposure studies (see acute inhalation toxicity).