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EC number: 231-592-0 | CAS number: 7646-85-7
Table 1. Influence of topical zinc chloride on plasma zinc
Diet and topical application
Treatment time (h)
114.6 ± 5.2*
74.6 ± 2.5
63.2 ± 3.2
Oil + Zinc
114.8 ± 3.7*
182.5 ± 8.9* # @
*Significantly higher than groups receiving oil without zinc, P < 0.001
#Significantly higher than the group receiving oil plus zinc for 8 hr, P < 0.001
@Significantly higher than control group, P < 0.001
Other data: There was no trace of Oil Red O stain in the area outside of the bandage in any of the animals tested, indicating that leakage did not occur. Therefore, the possibility of oral intake of zinc was discounted. Food intake was similar among all groups.
The effect (effect on plasma zinc concentration) of topical administration of zinc chloride was tested in pregnant rats consuming a diet deficient in zinc.
Four groups of rats were fed a zinc-deficient diet for 24 h. Half of the animals were treated during this period with a topical application of oil saturated with zinc chloride, for the full 24 h in one group, and for the last 8 h in the other. In the remaining two groups, oil without zinc chloride was applied under the same conditions as described above, and in all cases oral ingestion of the supplement was prevented. At the end of the 24 h period, the animals were sacrificed and plasma zinc was determined. An additional group of animals consuming a diet adequate in zinc was sacrificed without any treatment to provide control values of normal plasma zinc.
Rats consuming the deficient diet and without topical zinc supplementation had plasma zinc values significantly lower than all other groups after 24 h. Animals receiving zinc supplementation for 8 h had plasma levels similar to those of the control group fed an adequate zinc diet and significantly higher than those of rats that received no zinc application to the skin. In animals in which zinc was applied for 24 h, plasma zinc values were significantly higher than in any other group, including normal controls.
In conclusion, zinc was absorbed in clinically significant amount after topical application of zinc chloride in pregnant rats consuming a zinc deficient diet.
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