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EC number: 269-057-9 | CAS number: 68186-95-8 An inorganic pigment that is the reaction product of high temperature calcination in which zirconium (IV) oxide, silicon oxide, and vanadium (IV) oxide in varying amounts are homogeneously and ionically interdiffused to form a crystalline matrix of zircon. Its composition may include any one or a combination of the modifiers alkali or alkaline earth halides.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1991-08-01 to 1991-08-15
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study reliable without restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Version / remarks:
- adopted 1981-05-12
- Deviations:
- yes
- Remarks:
- no vehicle control group was used; no acclimatisation period was stated; it was not stated if a dynamic air flow of 12 to 15 air changes per hour was used; no equilibrium period was stated; clinical observations only at least once on workday
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Zirconium vanadium blue zircon
- EC Number:
- 269-057-9
- EC Name:
- Zirconium vanadium blue zircon
- Cas Number:
- 68186-95-8
- Molecular formula:
- (Zr, V)SiO4
- IUPAC Name:
- silicon(4+) vanadium(4+) zirconium(4+) hexaoxidandiide
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): Sicocer F türkis 2504
- Physical state: solid (powder)/blue
- Storage condition of test material: was stored at room temperature
- Homogeneity: was guaranteed by high purity
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS - strain: SPF Wistar/Chbb:THOM
- Age at study initiation: approx. 8 - 9 weeks
- Weight at study initiation: males (mean): 285 +/- 12.3 g; females (mean): 190 +/- 5.7 g
- Housing: housed singly in cages type DK III of Becker, without bedding
- Diet (ad libitum during the post exposure period): KLIBA rat/mouse/hamster laboratory diet 24-343-4 10 mm pellets, Klingentalmühle AG, CH-4303 Kaiseraugst, Switzerland
- Water (ad libitum during the post exposure period): drinking water
ENVIRONMENTAL CONDITIONS - the animals were kept in fully air-conditioned rooms
- Temperature: 20 - 24 °C
- Relative humidity: 30 - 70 %
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- nose/head only
- Vehicle:
- other: Aerosil and clean air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: head-nose inhalation system INA 20 (glass-steel construction, BASF Aktiengesellsschaft, volume V ~55 L): the animals were restrained in tubes and their snouts projected into the inhalation chamber.
- System of generating particulates/aerosols: the aerosol was produced with a dosing -wheel dust generator (Gericke/BASF) and compressed air.
A glass cyclonic separator (BASF) was connected downstream with the generator.
The concentration was adjusted by varying the rotation of the metering disc.
- Source and rate of air/method of conditioning air/treatment of exhaust air: the following air flow (supply air) was set: 1,500 L/h
The exposure system was placed in an air-conditioned laboratory.
By means of an exhaust air system the pressure ratios in the inhalation system were adjusted in such a way that the amount of exhaust air was about 10 % lower (excess pressure). This ensured that the mixture of test substance and air was not diluted with laboratory air in the breathing zones of the animals.
- Method of particle size determination: 30 minutes after the beginning of the test at the earliest, one sample was taken per test group for the particle size analysis (equipment: Stack Sampler Mark III (Andersen), vacuum compressed air pump (Millipore), sampling probe (internal diameter 6.9 mm), balance (Sartorius M3P and Mettler AE 240), evaluation unit (IBM-PC with software PGA).
Before the sampling, the impactor was equipped with glass-fiber collecting discs and a backup particle filter. The impactor was connected to the pump and the test apparatus, and one sample (9 L) was taken.
The impactor was taken apart, and the collecting discs and the backup particle filter were weighed.
The contents of the pre-impactor as well as the amounts of the material adsorbed on the walls of the impactor and in the sampling probe (wall losses) were also determined quantitatively.
- Temperature and humidity: the humidity in the inhalation system was not measured due to technical reasons. It is assumed that deviations of humidity values from the guideline requirements (especially low humidity in dust aerosol) did not influence the test results, because of the relative short exposure time.
The temperature in the inhalation system was measured continuously and recorded once.
TEST ATMOSPHERE
- Nominal concentration: the nominal concentration was calculated from the amount of substance consumed and the air flow.
- Brief description of analytical method used: gravimetric determination of the inhalation atmosphere concentration (apparatus: vacuum compressed air pump (Millipore), filtration equipment with probe (internal diameter: 4 mm, (Millipore)), filter (MN 85/90 Bf (d = 4.7 cm), sampling velocity 1.25 m/s, sampling amount 2 L, sampling frequency 1 sample about hourly)(balance: Mettler AT 250)
The preweighed filter was placed into the filtration equipment. By means of a vacuum compressed air pump a volume of the dust aerosol was drawn through the filter.
The dust concentration in mg/L was calculated from the difference between the preweight of the filter and the weight of the filter after sampling, with reference to the sample volume of the inhalation atmosphere. The concentrations were corrected for the amount of the added excipient.
- Samples taken from breathing zone: yes
VEHICLE
- Justification of choice of vehicle: the test substance was mixed with 1 wt% of aerosil in order to achieve a more uniform dust concentration in air.
TEST ATMOSPHERE (if not tabulated)
- MMAD* (Mass median aerodynamic diameter) / GSD (Geometric st. dev.): MMAD: 2.6 µm (GSD: 3.2)(respirability*: 89 %)
* the amounts of the material determined in the particle size analysis were not corrected for the additive
** respirable dust fraction that might reach the alveolar region, obtained from the results of the particle size analysis - Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- please refer "details on inhalation exposure" above
- Duration of exposure:
- 4 h
- Concentrations:
- Actual concentration: 5.1 +/- 0.46 mg/L
Nominal concentration: 113 mg/L - No. of animals per sex per dose:
- 5 males / 5 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: the body weight of the animals was checked before the beginning of the test, after 7 days and at the end of the observation period. Clinical findings were recorded for each animal separately several times during exposure and at least once each workday in the observation period (no clinical observations were performed on test days 2, 3, 9 and 10 (holiday or weekend). A check for dead animals was made daily.
- Necropsy of survivors performed: yes; at the end of the 14-day observation period the animals were sacrificed with CO2 and were subjected to gross-pathological examination. - Statistics:
- The statistical evaluation of the dose-response relationship was carried out using FORTRAN program AKPROZ. Depending on the data of the dose-response relationship obtained by way of experiment, this program is used to estimate the LC50 or to perform a Probit analysis (see Finney, D.J. (1971): "Probit Analysis", Cambridge University Press). Estimation of the LC50 will produce types LC50 greater, LC50 about, or LC50 smaller. If results are Type LC50 greater or LC50 smaller, an additional binominal test is carried out (Witting, H. (1974): "Mathematical Statistik", B.G. Teubner, Stuttgart, pp. 32 -35.), in order to verify these statements statistically, if necessary.
The calculation of the particle size distribution was carried out in the Deparment of Toxicology of BASF Aktiengesellschaft on the basis of mathematical methods for evaluating particle measurements (DIN 66141: Darstellung von Korngrößenverteilungen, DIN 66151: Partikelgrößenanalyse (Beuth-Vertrieb GmbH, D-W1000 Berlin 30 and D-W5000 Köln 1).
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 5.1 mg/L air (analytical)
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: The statistical reliability is 99 %.
- Mortality:
- No mortality occurred at the limit concentration of 5.1 mg/L.
- Clinical signs:
- other: During exposure and in the post-exposure observation period: clinical examination showed accelerated respiration in all animals during the exposure period and post exposure on exposure day (1/2 h - day 0 (post-exposure on exposure day). No abnormalities w
- Body weight:
- Body weight gain was not influenced in male animals. The female rats weight gain was reduced over the whole post exposure period.
- Gross pathology:
- No pathologic findings were noted in sacrificed animals.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- LC50 (male and female rats; 4 hours) > 5.1 mg/L
According to the EC-Commission directive 67/548/EEC and its subsequent amendments, the test substance is not classified as acute toxic via the inhalation route.
According to the EC-Regulation 1272/2008 and subsequent regulations, the test item is not classified as acute toxic via the inhalation route.
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