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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Non-standard investigation; published study

Data source

Reference
Reference Type:
publication
Title:
Histological findings in the skin of animals after percutaneous damage by hydrofluoric and hexafluorosilicic acid
Author:
Alhassan A & Zink P
Year:
1982
Bibliographic source:
Zeitschrift fur Rechtsmedizin 88(4):239-47

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Non-standard invetsigation of the histology of hexafluorosilic acid burns in rats, guinea pigs and pigs
GLP compliance:
no
Remarks:
: punlished study

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Hexafluorosilicic acid (concentrated) and hydrofluoric acid

Test animals

Species:
other: rat, guinea-pig, pig
Strain:
not specified

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
water
Controls:
not required
Duration of treatment / exposure:
No data
Observation period:
No data
Number of animals:
No data

Results and discussion

In vivo

Other effects:
Necrosis and oedema; not scored according to standard criteria.

Any other information on results incl. tables

The intact skin was not generally affected by the acids. Areas injured before application of the acid showed, however, a continuous spreading of necrosis in the deeper regions. The first histological changes were noticed 1 hour after the application and were seen long before any macroscopic reaction. The main characteristic findings were the hypocellular necrosis and oedema reaching as far as the subcutis. The necrosis showed sharp leukocyte demarcations.

Applicant's summary and conclusion

Interpretation of results:
corrosive
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The findings of this non-standard investigative study are consistent with the current 'Corrosive' classification of the substance.
Executive summary:

In a non-standard investigative study, the morphological changes in the skin of animals were studied after application of concentrated hydrofluoric and hexafluorosilicic acid. The intact skin was not generally affected by the acids. Areas injured before application of the acid showed, however, a continuous spreading of necrosis in the deeper regions. The first histological changes were noticed 1 hour after the application and were seen long before any macroscopic reaction. The main characteristic findings were the hypocellular necrosis and oedema reaching as far as the subcutis. The necrosis showed sharp leukocyte demarcations. The findings of this non-standard investigative study are consistent with the current 'Corrosive' classification of the substance.