Registration Dossier

Administrative data

Description of key information

No acute toxicity data have been identified for the substance: no testing has been performed and non is proposed.  The substance is classified as (R34) corrosive according to Directive 67/548/EEC (19th ATP), therefore acute toxicity will be dominated by local (site of contact) irritant and corrosive effects.  Testing of the substance for acute toxicity is not justified on scientific grounds and for reasons of animal welfare.

Key value for chemical safety assessment

Additional information

No data are available. The acute oral, dermal and inhalation toxicity is likely to be dominated by local (site of contact) effects as a consequence of the corrosivity of the substance.

The NTP review of toxicological data reports an acute oral LD50 in the rat of 430 mg/kg bw (RTECS, secondary source); this value suggests that the substance should be classified as (R22) 'Harmful if swallowed', however its relialiity cannot be assessed. An older and non-standard study of very limited reliability (Simonin & Pierron, 1937) also indicates that hexafluorosilicic acid of high acute toxicity. The authors report a lethal oral dose of 200 mg/kg bw and a lethal dermal dose of 250 mg/kg bw in the guinea pig.

Justification for classification or non-classification

The NTP review of toxicological data reports an acute oral LD50 in the rat of 430 mg/kg bw (RTECS, secondary source); this value suggests that the substance should be classified as (R22) 'Harmful if swallowed', however its relialiity cannot be assessed. No change to the current classification is proposed in the absence of any reliable data.