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Description of key information

No acute toxicity data have been identified for the substance: no testing has been performed and non is proposed. The substance is classified as H314 – Causes severe skin burns and eye damage according to CLP Regulation (No. 1272/2008 of 16 December 2008), therefore acute toxicity will be dominated by local (site of contact) irritant and corrosive effects. Testing of the substance for acute toxicity is not justified and was waived based on GLP Regulation Annex VII, column 2 specific rules of adaptation of 18 December 2006.

The boundary composition reports that H2SiF6 may contain “Free hydrogen fluoride, expressed as HF (%): max 15 %on dry basis”. Hydrogen fluoride has a harmonized classification in place.

Based on the classification of mixtures, classification shall therefore be given based on the % HF concentration.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

No reliable data are available. The acute oral, dermal and inhalation toxicity is likely to be dominated by local (site of contact) effects as a consequence of the corrosivity of the substance. Further testing was waived based on GLP Regulation Annex VII, column 2 specific rules of adaptation of 18 December 2006.

The boundary composition reports that H2SiF6 may contain “Free hydrogen fluoride, expressed as HF (%): max 15 %on dry basis”.

Hydrogen fluoride has a harmonized classification in place, and it is classified for Acute toxicity hazard as following :

Oral Acute tox 2; (LD50 Oral: Not available: ATE = 5)

Dermal Acute tox 1; (LD50 Dermal: Not available: ATE = 5)

Inhalation Acute tox 2; (LD50 Inhalation: Not available: ATE = 100).

Based on the classification of mixtures, classification of a substance containing HF as impurity result to be the following. Classsification shall therefore be given based on the % HF concentration.

 

Oral Acute Tox Cons:

Acute tox 2: ATE mix < 50 => CHF  >100*5/50 = 10 %

Acute Tox 3: ATE mix < 300 => CHF >100*5/300 = 1,6 %

Acute Tox 4: ATE mix < 2000 => CHF >100*5/2000 = 0,25%

 

Dermal Acute Tox Cons:

Acute tox 1: ATE mix < 50 => CHF  >100*5/50 = 10 %

Acute Tox 2: ATE mix < 200 => CHF >100*5/200 =2,5%

Acute Tox 3: ATE mix < 1000 => CHF >100*5/1000 = 0,5 %

Acute Tox 4: ATE mix < 2000 => CHF >100*5/2000 = 0,25%

 

Inhalation Acute Tox Cons:

Acute tox 2: ATE mix < 500 => CHF  >100*100/500 = 20 %

Acute Tox 3: ATE mix < 2500 => CHF >100*100/2500 = 4 %

Acute Tox 4: ATE mix < 20000 => CHF >100*100/20000 = 0,5%

Justification for classification or non-classification

Acute toxicity testing was waived based on corrosive properties of the substance. There is no reliable information to classify Hexafluorisilic acid for acute oral, dermal or inhalation toxicity based CLP Regulation (No. 1272/2008 of 16 December 2008).