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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Older paper (Kick et al, 1935) cited in published review

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Fluorine in animal nutrition.
Author:
Kick CH, RM Bethke, BH Edgington, OHM Wilder, PR Record, W Wilder, TJ Hill, & SW Chase
Year:
1935
Bibliographic source:
OHIO Agricultural Experiment Station Bulletin 558, Wooster, OH, 77 pp.
Reference Type:
secondary source
Title:
Sodium Hexafluorosilicate [CASRN 16893-85-9] and Fluorosilicic Acid [CASRN 16961-83-4] Review of Toxicological Literature
Author:
Haneke KE & Carson BL
Year:
2001
Bibliographic source:
National Institute of Environmental Health Sciences P.O. Box 12233 Research Triangle Park, North Carolina 27709 Contract No. N01-ES-65402

Materials and methods

Objective of study:
absorption
Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
The authors investigated the dietary availability of fluoride from hexafluorosilicate.
GLP compliance:
no
Remarks:
: older study

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Sodium hexafluorosilicate
Radiolabelling:
no

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: feed
Vehicle:
unchanged (no vehicle)
Duration and frequency of treatment / exposure:
Ad libitum (in the diet) for 22-23 days
Doses / concentrations
Remarks:
Doses / Concentrations:
0.16% sodium hexafluorosilicate in the diet
No. of animals per sex per dose:
Not reported
Control animals:
not specified

Results and discussion

Preliminary studies:
No data

Toxicokinetic / pharmacokinetic studies

Details on absorption:
The mean amount of fluorine absorbed was 65.1% and that retained was 31.0%.
Details on distribution in tissues:
Not investigated
Details on excretion:
The average amounts of fluorine were 94.4 mg in faeces and 91.9 mg in urine.

Metabolite characterisation studies

Metabolites identified:
no
Details on metabolites:
Not investigated

Any other information on results incl. tables

The average amounts of fluorine were 94.4 mg in faeces and 91.9 mg in urine. The mean amount of fluorine absorbed was 65.1% and that retained was 31.0%.

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): other:
The results of this study demonstrate the bioavailability of fluorine from fluorosilicate administered in the diet.
Executive summary:

Rats were fed a diet containing 0.16% sodium hexafluorosilicate supplemented in a corn-soybean oilmeal-casein ration ad libitum for 22-23 days. The excretion of fluoride was measured and retention estimated. The average amounts of fluorine were 94.4 mg in faeces and 91.9 mg in urine. The mean amount of fluorine absorbed was 65.1% and that retained was 31.0%. The results of this study demonstrate the bioavailability of fluorine from fluorosilicate administered in the diet.