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Toxicological information

Direct observations: clinical cases, poisoning incidents and other

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Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Published case report involving sodium hexafluorosilicate

Data source

Reference
Reference Type:
publication
Title:
CASE HISTORY OF ACUTE POISONING BY SODIUM FLUOROSILICATE
Author:
DADEJ N, KOSIMIDER K, MACHOY Z & SAMUJILO D
Year:
1987
Bibliographic source:
FLUORIDE; 20 (1). 1987. 11-13.

Materials and methods

Study type:
clinical case study
Endpoint addressed:
acute toxicity: oral
Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Published case report involving sodium hexafluorosilicate
GLP compliance:
no
Remarks:
: not relevant

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Sodium hexafluorosilicate

Method

Subjects:
One female (32 years old); intentional (suicidal) exposure
Route of exposure:
oral
Reason of exposure:
intentional
Exposure assessment:
estimated

Results and discussion

Clinical signs:
Immediate vomiting, then facial numbness, diarrhoea, diaphoresis, muscle spasms, weakness, abdominal pain, dyspnoea, shallow breathing, and cramps of the palms, feet, and legs. Tachycardia and tachypnea were observed. After 12 hours, generalized weakness and enlargement of the liver continued.

Any other information on results incl. tables

Treatment with calcium compounds (calcium carbonate initially; calcium lactogluconate for ten days after life-threatening symptoms had diminished) resulted in recovery within 21 days. Fluoride levels in serum and urine were 5.130 and 235.60 mg/dm3, respectively, on day 2 of hospitalization. Treatment with calcium compounds (calcium carbonate and calcium lactogluconate) immediately returned levels to normal. The following day, the levels dropped to 0.399 and 15.39 mg/dm3, respectively; by day 20, the levels were 0.067 and 0.87 mg/dm3, respectively.

Applicant's summary and conclusion

Conclusions:
The signs and symptoms of toxicity in this poisoning case are consistent with fluoride poisoning.
Executive summary:

A case report of a suicide attempt is reported.

A female chemical plant worker (32 years old) who ingested three teaspoons of sodium hexafluorosilicate immediately began vomiting, and then experienced facial numbness, diarrhea, diaphoresis, muscle spasms, weakness, abdominal pain, dyspnea, shallow breathing, and cramps of the palms, feet, and legs. Tachycardia and tachypnea were observed. After 12 hours, generalized weakness and enlargement of the liver continued. Treatment with calcium compounds (calcium carbonate initially; calcium lactogluconate for ten days after life-threatening symptoms had diminished) resulted in recovery within 21 days. Fluoride levels in serum and urine were markedly elevated; no effect were apparent on the level of fluoride in nails. The signs and symptoms of toxicity in this poisoning case are consistent with fluoride poisoning.