Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

Currently viewing:

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: limited documented study report, with restrictions (e.g. no local effects recorded), sufficient for risk assessment

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1973
Report date:
1973
Reference Type:
publication
Title:
Acute toxicologic evaluation of Santocure vulcanization accelerator
Author:
Randall, D.J. and Bannister, R.M.,
Year:
1990
Bibliographic source:
Acute Toxic. Data 1 (2), 105-106

Materials and methods

Principles of method if other than guideline:
A 40% solution-suspension of CBS in corn oil was applied for 24 h directly to the clipped intact skin of New Zealand albino rabbits at doses of 5010 and 7940 mg/kg bw (1 and 2 animals, resp.) using semi-occlusive dressing. A 14-d observation period followed application.
GLP compliance:
no
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
N-cyclohexylbenzothiazole-2-sulfenamide
EC Number:
202-411-2
EC Name:
N-cyclohexylbenzothiazole-2-sulfenamide
Cas Number:
95-33-0
Molecular formula:
C13H16N2S2
IUPAC Name:
N-(1,3-benzothiazol-2-ylsulfanyl)cyclohexanamine
Details on test material:
IUCLID4 Test substance: other TS: as prescribed by chapter 1 in dataset of Monsanto

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male/female

Administration / exposure

Type of coverage:
semiocclusive
Vehicle:
corn oil
Duration of exposure:
24 h
Doses:
5010, 7940 mg/kg bw.
No. of animals per sex per dose:
1-2/dose.
Control animals:
no

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 7 940 mg/kg bw
Based on:
test mat.
Remarks on result:
other: Clinical signs: reduced appetite and activity three to five days.
Mortality:
No mortality occured (5010 mg/kg bw (0/1), 7940 mg kg bw (0/2)).
Clinical signs:
other: Reduced appetite and activity three to five days.
Gross pathology:
Viscera of animals appeared normal at sacrifice.

Any other information on results incl. tables

No mortality occured (5010 mg/kg bw (0/1), 7940 mg kg bw (0/2)).

Clinical signs: reduced appetite and activity three to five days.

Viscera of animals appeared normal at sacrifice.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
LD50 > 7940 mg/kg bw.
Executive summary:

The acute dermal toxicity of the test substance CBS was evaluated with New Zealand Albino rabbits in a limited documented study. A 40% solution-suspension of CBS in corn oil was applied for 24 h directly to the clipped intact skin of New Zealand albino rabbits at doses of 5010 and 7940 mg/kg bw (1 and 2 animals, resp.) using semi-occlusive dressing. A 14 -d observation period followed application. No mortality was observed up to 7940 mg/kg bw. Clinical signs noted included reduced appetite and activity for 3 to 5 days. Viscera of animals appeared normal at sacrifice (Monsanto 1973).