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Diss Factsheets

Physical & Chemical properties

Water solubility

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Principles of method if other than guideline:
The May method (May, W. E., Wasik, S. P., and Freeman, D. H. Anal. Chem. 50 (1) 175-178 (1978)) was used.
It produces a saturated aqueous solution of the chemical of interest by passing the buffer through a column packed with glass beads (60-80 mesh) that have been previously coated with the compounds.
GLP compliance:
not specified
Type of method:
column elution method
Water solubility:
0.24 mg/L
Conc. based on:
test mat.
Temp.:
21 °C
pH:
5
Key result
Water solubility:
0.32 mg/L
Conc. based on:
test mat.
Temp.:
21 °C
pH:
7
Water solubility:
0.48 mg/L
Conc. based on:
test mat.
Temp.:
21 °C
pH:
9
Details on results:
The substance appeared as one peak in its analysis by HPLC.
Conclusions:
The water solubility of CBS was determined by using column elution method to be 0.32 mg/l at 21 °C and pH 7 (Monsanto, 1980).
Executive summary:

The water solubility of CBS was determined by using column elution method also referred to as the May method.



It produces a saturated aqueous solution of the chemical of interest by passing the buffer through a column packed with glass beads (60-80 mesh) that have been previously coated with the compounds. Subsequent analysis of the aqueous solution via HPLC reveals the dissolved amount of substance in water.


 


The solubility of N-cyclohexylbenzothiazole-2-sulphenamide in water was examined in solutions of three pH values (5, 7, 9) at 21 °C:


 























pHSolubility [mg/l]temperature
50.24 ± 0.0121 °C
70.32 ± 0.01
90.48 ± 0.03

 

Description of key information

The water solubility of CBS was determined by using column elution method to be 0.32 mg/l at 21 °C and pH 7 (Monsanto, 1980).

Key value for chemical safety assessment

Water solubility:
0.32 mg/L
at the temperature of:
21 °C

Additional information