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Toxicological information

Direct observations: clinical cases, poisoning incidents and other

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Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
review article or handbook
Title:
Skin irritation in humans
Author:
Biotech Index
Year:
1970
Bibliographic source:
Biotech Index NG01970

Materials and methods

Study type:
study with volunteers
Endpoint addressed:
skin irritation / corrosion
Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Method followed unknown, data from handbook.
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
Glycerides, C8-18 and C18-unsatd.
IUPAC Name:
Glycerides, C8-18 and C18-unsatd.
Constituent 2
Reference substance name:
Glycerides, C8-18 and C18-unsatd.
EC Number:
266-946-3
EC Name:
Glycerides, C8-18 and C18-unsatd.
IUPAC Name:
266-946-3
Constituent 3
Reference substance name:
67701-28-4
Cas Number:
67701-28-4
IUPAC Name:
67701-28-4
Details on test material:
- Name of test material (as cited in study report): Coconut oil (CAS N° 8001-31-8, EC N° 232-282-8); under the SDA nomenclature, the name of this substance is ‘Glycerides, C8-18 and C18-unsatd.’

Method

Type of population:
general
Subjects:
No information
Ethical approval:
not specified
Route of exposure:
dermal
Reason of exposure:
intentional
Exposure assessment:
not specified

Results and discussion

Clinical signs:
No data
Outcome of incidence:
No irritation observed.

Any other information on results incl. tables

None

Applicant's summary and conclusion

Conclusions:
The test substance is not irritating to human skin.
Executive summary:

According to the Biotech Index, ‘glycerides, C8-18 and C18-unsatd.’ (as coconut oil) is not irritating to human skin after 4 h of exposure (Biotech Index, 1970).

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