Oils, vegetable, deodorizer distillates

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

From 23 April, 2010 to 20 July, 2010

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Deviations:

no

Principles of method if other than guideline:

Not applicable

GLP compliance:

yes (incl. QA statement)

Type of method:

flask method

Key result

Water solubility:

31 mg/L

Temp.:

20 °C

pH:

>= 5.1 - < 5.5

Details on results:

- Calibration range: 1 to 100 mg carbon/L pure water in the case of TC-calibration; 1 to 100 mg carbon/L pure water in the case of IC-calibration
- Regression coefficient (r²): At least 1.0000 in the case of TC; at least 0.9999 in the case of IC
- Typical calibration curve: y = 4.5706x + 0.4987 in the case of TC; y = 4.6248x + 0.2071 in the case of IC
- Limit of detection: LOD TC: 0.9498 mg carbon/L; LOD IC: 1.5941 mg carbon/L
- Limit of quantification: LOQ TC: 3.3824 mg carbon/L; LOQ IC: 5.6524 mg carbon/L
- LOQ Test item: 2 mg C/L corresponding to 2.6 mg test item/L

None

Conclusions:

Under the study conditions, the water solubility of test substance was determined to be 31 mg/L at 20 ± 2°C.

Executive summary:

The water solubility of 'oils, vegetable, deodorizer distillates' in water was determined according to OECD Guideline 105 and EU Method A.6. The water solubility of test substance was estimated to be lower than 0.01 g/L in a preliminary test (non-GLP). Therefore, the column elution method was first selected for the main test. However, the column elution method was found to be not feasible and thus the flask method was finally used for the determination of the water solubility. The saturation mass concentration was estimated using the TOC method. Under the conditions of the study, the water solubility of test substance was determined to be 31 mg/L at 20 ± 1°C (Mollandin, 2010a).

Description of key information

The water solubility of 'oils, vegetable, deodorizer distillates' in water was determined according to OECD Guideline 105 and EU Method A.6.

Key value for chemical safety assessment

Water solubility:

40 mg/L

at the temperature of:

20 °C

Additional information

Water solubility values of the test substance and category members are as follows:

Oils, vegetable deodoriser distillates = 31 mg/L

Glycerides, C16-18 and C18-unsatd., deodorizer distillates = 6.4 mg/L

Lauric fats deodorizer distillates = 40 mg/L

Soybean oil, deodorizer distillates = 28 mg/L

The higher value of 40 mg/L was selected for the chemical safety assessment which will represent higher exposure to water, STP as well as absorption potential in human body.