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EC number: 401-540-3 | CAS number: -
Due to the findings described above (LD50 oral in rats > 5000 mg/kg bw, LD50 dermal in rats > 2000 mg/kg bw) Pigment Red 254 has not to be classified as acute orally and dermally toxic according to the criteria laid down in Directive 67/548/EEC and in Regulation (EC) No 1272/2008.
It can reasonably be deduced that Pigment Red 254 does not exert systemic toxic effects after acute inhalation exposure and thus does not have to be classified according to the criteria laid down in Directive 67/548/EEC and in Regulation (EC) No 1272/2008, because
- Pigment Red 254 did not cause lethal effects after administration of a single oral dose of up to 5000 mg/kg bw in rats
- Pigment Red 254 did not cause lethal effects after administration of a single dermal dose up to 2000 mg/Kg bw in rats
- Pigment Red 254 does not have to be classified as skin or eye irritating or as skin sensitzing, and
- it is unlikely that Pigment Red 254 becomes systemically bioavailable after inhalation due to its extremely low solubility in water and n-octanol.
Therefore, it is concluded that Pigment Red 254, when aerosolized, is an inert dust and that testing is not necessary to reach the scientific conclusion that classification is not warrantable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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