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EC number: 401-540-3 | CAS number: -
The animals were killed 168 h p.a.. During the 168 h, 0.3 resp. 0.6 % of the applied radioactivity was found in the urine; 0.3 rsp. 0.4 % were just detected after 24 h in the urine. These small amounts are interpreted as technic-related faecalic impurities.
The part which was incorporated in the faeces were in average 119.7 % (low dose group) rsp. 96.0 %. The corresponding fraction after 24 h was 101.4 % rsp. 79.7 %. In both dosage groups only negligible amounts of the radioactive substance were detected in the organs and the tissue, in the intestinal tract, in the blood and in the carcasse. The maximal concentration in the blood was 0.139 µg/g (low dosage group) rsp. 1.152 µg/g and in the plasma 0.140 rsp. 1.048 µg/g. The maxima were reached 1 to 2 h after application. As the concentration is closed to the detection limit the kinetics of the elimination and the area under the curve could not be calculated.
From the study can be stated that the notified substance is not bioavailable when it is applied once orally under the conditions mentioned above.
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