1-vinyl-2-pyrrolidone

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Comparable to guideline with acceptable restrictions (mostly due to reduced reporting in times before GLP)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1963

Report date:

1963

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

1-vinyl-2-pyrrolidone

EC Number:

201-800-4

EC Name:

1-vinyl-2-pyrrolidone

Cas Number:

88-12-0

Molecular formula:

C6H9NO

IUPAC Name:

1-ethenylpyrrolidin-2-one

Details on test material:

- Name of test material (as cited in study report): Vinylpyrrolidon roh (crude)
- Physical state: liquid

Test animals

Species:

rat

Strain:

not specified

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Heigl
- Weight at study initiation: males 136-215 g; females 128-186 g

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

water

Details on oral exposure:

VEHICLE
- Concentration in vehicle: 2% (200 mm3/kg bw) or 20% (800-1600 mm3/kg bw)


MAXIMUM DOSE VOLUME APPLIED: 2.15 mL (10 mL/kg bw)

Doses:

200, 800, 1000, 1250 and 1600 mm3/kg bw, corresponding to ca. 209, 834, 1043, 1304 and 1669 mg/kg bw; calculated with a density of 1.043 g/mL)

No. of animals per sex per dose:

5 (exception 200mm3/kg bw had total 5 animals of both sexes)

Control animals:

no

Details on study design:

- Duration of observation period following administration: 7 days
- Frequency of observations and weighing: Weighing was only at the beginning of the study for dose calculation. Observation of clinical signs was several times on the day of administration and once daily afterwards with the exception of weekends and on holidays.
- Necropsy of survivors performed: yes

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

1 043 mg/kg bw

Remarks on result:

other: original data: LD50 = 1.0 mL/kg bw; calculated with a density of 1.043 g/mL

Mortality:

200 mm3/kg bw: 0/5 animals died
800 mm3/kg bw: 0/10 animals died
1000 mm3/kg bw: 5/10 animals died within 7 days (3/10 within 48 hrs)
1250 mm3/kg bw: 8/10 animals died within 7 days (5/10 within 48 hrs)
1600 mm3/kg bw: 8/10 animals died within 7 days (7/10 within 48 hrs)

Clinical signs:

other: Staggering gait, partially draged hindlimbs, slight apathy, abdominal position, ruffled fur, crusted eyelids; all signs were reversible within at least 3 days

Gross pathology:

Animals that died: livers spotted bright, lobules marked; spleen and kidneys brightened; stomach with lamellar bleedings
Sacrificed animals: nothing abnormal found